抄録
This microreview summarizes examples of Hf(OTf)4-mediated or -catalyzed organic reactions. Hafnium triflate possesses four strongly electron-withdrawing OTf groups, together with an ionic radius of intermediate range (Al < Ti < Hf, Zr < Sc < Ln), and has an oxophilic hard character typical of group IV metals. This Lewis acid shows outstanding performance in catalytic Friedel-Crafts acylation reactions and Mannich-type reactions of imines, hydrazones, and N,O-acetals. Several natural products have also been synthesized by use of Hf(OTf)4-mediated or -catalyzed reactions. Moreover, Hf(OTf)4 has a number of potent features in carbohydrate syntheses. Hf(OTf)4 possesses many unique characteristics that distinguish it from other Lewis acids. The unique characteristics of Hf(OTf)4 should make this compound a major candidate for selection as a Lewis acid in the future.
本文言語 | English |
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ページ(範囲) | 5485-5499 |
ページ数 | 15 |
ジャーナル | European Journal of Organic Chemistry |
巻 | 2015 |
号 | 25 |
DOI | |
出版ステータス | Published - 1 9月 2015 |