A new leishmanicidal saponin from Brunfelsia grandiflora

Hiroyuki Fuchino; Setsuko Sekita; Kanami Mori; Nobuo Kawahara; Motoyoshi Satake; Fumiyuki Kiuchi

doi:10.1248/cpb.56.93

A new leishmanicidal saponin from Brunfelsia grandiflora

Hiroyuki Fuchino, Setsuko Sekita, Kanami Mori, Nobuo Kawahara, Motoyoshi Satake, Fumiyuki Kiuchi

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O- β-D-glucopyranosyl 22 α-methoxyfurost-3β,26-diol 3-O-β-D-xylopyranosyl(1→3)-{β-D-glucopyranosyl(1→2)} -β-D-glucopyranosyl(1→4)-β-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.

Original language	English
Pages (from-to)	93-96
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	56
Issue number	1
DOIs	https://doi.org/10.1248/cpb.56.93
Publication status	Published - Jan 2008

Keywords

Brunfelsia grandiflora
Chiricsanango
Furostan
Leishmania
Solanaceae

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10.1248/cpb.56.93

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abstract = "A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O- β-D-glucopyranosyl 22 α-methoxyfurost-3β,26-diol 3-O-β-D-xylopyranosyl(1→3)-{β-D-glucopyranosyl(1→2)} -β-D-glucopyranosyl(1→4)-β-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.",

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AU - Satake, Motoyoshi

AU - Kiuchi, Fumiyuki

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A new leishmanicidal saponin from Brunfelsia grandiflora

Abstract

Keywords

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