Abstract
A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O- β-D-glucopyranosyl 22 α-methoxyfurost-3β,26-diol 3-O-β-D-xylopyranosyl(1→3)-{β-D-glucopyranosyl(1→2)} -β-D-glucopyranosyl(1→4)-β-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.
Original language | English |
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Pages (from-to) | 93-96 |
Number of pages | 4 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 56 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2008 |
Keywords
- Brunfelsia grandiflora
- Chiricsanango
- Furostan
- Leishmania
- Solanaceae