Synthesis of cinnolines via Rh(III)-catalysed dehydrogenative C-H/N-H functionalization: Aggregation induced emission and cell imaging

Sivakalai Mayakrishnan; Yuvaraj Arun; Chandrasekar Balachandran; Nobuhiko Emi; Doraiswamy Muralidharan; Paramasivan Thirumalai Perumal

doi:10.1039/c5ob02045j

Synthesis of cinnolines via Rh(III)-catalysed dehydrogenative C-H/N-H functionalization: Aggregation induced emission and cell imaging

Sivakalai Mayakrishnan, Yuvaraj Arun, Chandrasekar Balachandran, Nobuhiko Emi, Doraiswamy Muralidharan, Paramasivan Thirumalai Perumal

生命医科学研究所

研究成果: Article › 査読

59 被引用数 (Scopus)

抄録

Rhodium catalysed dehydrogenative C-H/N-H functionalization was developed to construct phthalazino[2,3-a]-/indazolo[1,2-a]cinnolines by reacting N-phenyl phthalazine/indazole with alkynes. The synthesized compounds exhibit prominent fluorescence properties in solid and aggregation states. Their application in cell imaging was investigated using various cancer cell lines.

本文言語	English
ページ（範囲）	1958-1968
ページ数	11
ジャーナル	Organic and Biomolecular Chemistry
巻	14
号	6
DOI	https://doi.org/10.1039/c5ob02045j
出版ステータス	Published - 2016

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10.1039/c5ob02045j

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引用スタイル

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abstract = "Rhodium catalysed dehydrogenative C-H/N-H functionalization was developed to construct phthalazino[2,3-a]-/indazolo[1,2-a]cinnolines by reacting N-phenyl phthalazine/indazole with alkynes. The synthesized compounds exhibit prominent fluorescence properties in solid and aggregation states. Their application in cell imaging was investigated using various cancer cell lines.",

author = "Sivakalai Mayakrishnan and Yuvaraj Arun and Chandrasekar Balachandran and Nobuhiko Emi and Doraiswamy Muralidharan and Perumal, {Paramasivan Thirumalai}",

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AU - Arun, Yuvaraj

AU - Balachandran, Chandrasekar

AU - Emi, Nobuhiko

AU - Muralidharan, Doraiswamy

AU - Perumal, Paramasivan Thirumalai

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AB - Rhodium catalysed dehydrogenative C-H/N-H functionalization was developed to construct phthalazino[2,3-a]-/indazolo[1,2-a]cinnolines by reacting N-phenyl phthalazine/indazole with alkynes. The synthesized compounds exhibit prominent fluorescence properties in solid and aggregation states. Their application in cell imaging was investigated using various cancer cell lines.

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