Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces

Kenichi Nagase; Jun Kobayashi; Akihiko Kikuchi; Yoshikatsu Akiyama; Hideko Kanazawa; Teruo Okano

Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces

Kenichi Nagase, Jun Kobayashi, Akihiko Kikuchi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

マテリアル創成工学科

研究成果: Paper › 査読

抄録

We prepared poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (poly(IPAAm-co-DMAEMA))-grafted brush surfaces on silica beads as Chromatographic matrices by surface-initiated atom transfer radical polymerization (ATRP). Utilizing poly(IPAAm-co-DMAEMA)-grafted silica beads as column matrixes, temperature-dependent elution profiles of anionic bioactive compounds were examined at various temperatures. The effect of electrostatic interaction on retention behavior of various types of anionic bioactive compounds was also discussed.

本文言語	English
ページ	4996-4997
ページ数	2
出版ステータス	Published - 1 12月 2006
イベント	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan 継続期間: 20 9月 2006 → 22 9月 2006

Conference

Conference	55th Society of Polymer Science Japan Symposium on Macromolecules
国/地域	Japan
City	Toyama
Period	20/09/06 → 22/09/06

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Link to publication in Scopus

引用スタイル

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title = "Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces",

abstract = "We prepared poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (poly(IPAAm-co-DMAEMA))-grafted brush surfaces on silica beads as Chromatographic matrices by surface-initiated atom transfer radical polymerization (ATRP). Utilizing poly(IPAAm-co-DMAEMA)-grafted silica beads as column matrixes, temperature-dependent elution profiles of anionic bioactive compounds were examined at various temperatures. The effect of electrostatic interaction on retention behavior of various types of anionic bioactive compounds was also discussed.",

keywords = "Bioactive compound, Cationic surface, Ion exchange chromatography, Living radical polymerization, Thermoresponsive surface",

author = "Kenichi Nagase and Jun Kobayashi and Akihiko Kikuchi and Yoshikatsu Akiyama and Hideko Kanazawa and Teruo Okano",

year = "2006",

month = dec,

day = "1",

language = "English",

pages = "4996--4997",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

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TY - CONF

T1 - Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces

AU - Nagase, Kenichi

AU - Kobayashi, Jun

AU - Kikuchi, Akihiko

AU - Akiyama, Yoshikatsu

AU - Kanazawa, Hideko

AU - Okano, Teruo

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We prepared poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (poly(IPAAm-co-DMAEMA))-grafted brush surfaces on silica beads as Chromatographic matrices by surface-initiated atom transfer radical polymerization (ATRP). Utilizing poly(IPAAm-co-DMAEMA)-grafted silica beads as column matrixes, temperature-dependent elution profiles of anionic bioactive compounds were examined at various temperatures. The effect of electrostatic interaction on retention behavior of various types of anionic bioactive compounds was also discussed.

AB - We prepared poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (poly(IPAAm-co-DMAEMA))-grafted brush surfaces on silica beads as Chromatographic matrices by surface-initiated atom transfer radical polymerization (ATRP). Utilizing poly(IPAAm-co-DMAEMA)-grafted silica beads as column matrixes, temperature-dependent elution profiles of anionic bioactive compounds were examined at various temperatures. The effect of electrostatic interaction on retention behavior of various types of anionic bioactive compounds was also discussed.

KW - Bioactive compound

KW - Cationic surface

KW - Ion exchange chromatography

KW - Living radical polymerization

KW - Thermoresponsive surface

UR - http://www.scopus.com/inward/record.url?scp=33846121650&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33846121650

SP - 4996

EP - 4997

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces

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Conference

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