Ru(II)-Catalyzed Regiospecific C-H/O-H Oxidative Annulation to Access Isochromeno[8,1-ab]phenazines: Far-Red Fluorescence and Live Cancer Cell Imaging

Sivakalai Mayakrishnan; Yuvaraj Arun; Chandrasekar Balachandran; Suresh Awale; Narayanan Uma Maheswari; Paramasivan Thirumalai Perumal

doi:10.1021/acsomega.7b00335

Ru(II)-Catalyzed Regiospecific C-H/O-H Oxidative Annulation to Access Isochromeno[8,1-ab]phenazines: Far-Red Fluorescence and Live Cancer Cell Imaging

Sivakalai Mayakrishnan, Yuvaraj Arun, Chandrasekar Balachandran, Suresh Awale, Narayanan Uma Maheswari, Paramasivan Thirumalai Perumal

生命医科学研究所

研究成果: Article › 査読

14 被引用数 (Scopus)

抄録

A facile ruthenium(II)-catalyzed regiospecific C-H/O-H oxidative annulation methodology was developed to construct isochromeno[8,1-ab]phenazines. This methodology delivers various advantages, such as scope for diverse substrates, tolerance to a range of functional groups, stability under air, and yields regioselective products. This methodology was successfully applied to synthesize far red (FR) fluorescent probes for live cancer cell imaging. The synthesized compounds displayed notable fluorescence properties in solution and thin-film. Their application in live cancer cell imaging was investigated using various cancer cell lines. The synthesized compound showed prominent FR fluorescence, with high quantum yield, and exhibited better cell-imaging properties, with excellent biocompatibility.

本文言語	English
ページ（範囲）	2694-2705
ページ数	12
ジャーナル	ACS Omega
巻	2
号	6
DOI	https://doi.org/10.1021/acsomega.7b00335
出版ステータス	Published - 30 6月 2017

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10.1021/acsomega.7b00335

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abstract = "A facile ruthenium(II)-catalyzed regiospecific C-H/O-H oxidative annulation methodology was developed to construct isochromeno[8,1-ab]phenazines. This methodology delivers various advantages, such as scope for diverse substrates, tolerance to a range of functional groups, stability under air, and yields regioselective products. This methodology was successfully applied to synthesize far red (FR) fluorescent probes for live cancer cell imaging. The synthesized compounds displayed notable fluorescence properties in solution and thin-film. Their application in live cancer cell imaging was investigated using various cancer cell lines. The synthesized compound showed prominent FR fluorescence, with high quantum yield, and exhibited better cell-imaging properties, with excellent biocompatibility.",

author = "Sivakalai Mayakrishnan and Yuvaraj Arun and Chandrasekar Balachandran and Suresh Awale and Maheswari, {Narayanan Uma} and Perumal, {Paramasivan Thirumalai}",

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AU - Mayakrishnan, Sivakalai

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AU - Perumal, Paramasivan Thirumalai

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