@article{e69f65b3fe8142b6b6ce097cf87427d7,
title = "RNA tetraplex as a primordial peptide synthesis scaffold",
abstract = "Peptide bond formation at the peptidyl transferase center on the ribosome is a crucial phenomenon in life systems. In this study, we conceptually propose possible roles of the RNA tetraplex as a scaffold for two aminoacyl minihelices that enable peptide bond formation. The basic rationale of this model is that {"}parallel{"} complementary templates composed of only 10-mer nucleotides can position two amino acids in close proximity, which is conceptually and essentially similar to the situation observed in ribosomes. Using supportive experimental data, we discuss the origin and evolution of peptide bond formation in early biological systems.",
keywords = "Minihelix, Peptide bond formation, RNA tetraplex, TRNA",
author = "Takuya Umehara and Takahiro Kitagawa and Yu Nakazawa and Hinako Yoshino and Ryohei Nemoto and Koji Tamura",
note = "Funding Information: We thank Professor Gota Kawai for helpful discussions. This work was supported by a grant from PRESTO (RNA and Biofunctions), the Japan Science and Technology Agency (JST), Japan , by Grants-in Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan (Grant No. 23657160 ) and by the program for development of strategic research center in private universities by MEXT, Japan .",
year = "2012",
month = aug,
doi = "10.1016/j.biosystems.2012.03.003",
language = "English",
volume = "109",
pages = "145--150",
journal = "BioSystems",
issn = "0303-2647",
publisher = "Elsevier Ireland Ltd",
number = "2",
}