Post _{イリジウム（III）錯体の機能化と生命科学および材料科学への応用} complexationfunctionalizationによるシクロメタレート型―金属錯体をビルディングブロックとする機能性分子の創製―

Cyclometalated iridium（III）（Ir （III）complexes（e.g.: fac-Ir （tolpy）₃（tolpy＝2（- 4'-tolyl）pyridine）, fac-Ir （ppy）₃（ppy＝2-phenylpyridine）are extremely stable in water and organic solvents and are used as organic light emission diodes（OLEDs）and cell imaging materials due to its high emission properties. In the syntheses of various cyclometalated metal complexes, appropriate ligands _difficult are _to prepared _synthesize and _various then used _metal for _complexes the complexation _{that contain} with metal _labile salts. _and Therefore, _{／or unstable} it is _functional generally groups under harsh reaction conditions（such as high temperature）. In this review, we describe regioselective substitution reactions and successive conversions of the cyclometalated Ir （III）complexes to many derivatives for the synthesis of the functionalized Ir （III）complexes such as Ir complex-peptide hybrids（IPHs）, Ir complex-chromophore hybrids（ICHs）, which is called “post-complexation functionalization”, and their application to biomedical and material sciences. The synthesis of heteroleptic triscyclometalated Ir complexes via Zn²＋-promoted degradation reactions is also described.