TY - GEN
T1 - Microfluidic device for capturing circulating tumor cells - Separation by cell size and rigidity
AU - Konishi, Tomoki
AU - Okano, Hiromasa
AU - Suzuki, Takahiro
AU - Ariyasu, Shinya
AU - Suzuki, Toshihiro
AU - Abe, Ryo
AU - Aoki, Shin
AU - Hayase, Masanori
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Effect of fluid velocity on cell size sorting by a deterministic lateral displacement (DLD) device was studied. Circulating tumor cells (CTCs) tends to be larger compared to benign blood cells, and DLD sorting devices have been studied for CTC separation. However, high separation efficiency is not expected by only size sorting. We focused on cell deformability, and effect of fluid velocity on separation behavior in a simple DLD device was observed. It was found that benign lymphocytes tends to behave like smaller cells at high velocity, while no obvious difference along fluid velocity was observed with cultured SP2/0 tumor cells.
AB - Effect of fluid velocity on cell size sorting by a deterministic lateral displacement (DLD) device was studied. Circulating tumor cells (CTCs) tends to be larger compared to benign blood cells, and DLD sorting devices have been studied for CTC separation. However, high separation efficiency is not expected by only size sorting. We focused on cell deformability, and effect of fluid velocity on separation behavior in a simple DLD device was observed. It was found that benign lymphocytes tends to behave like smaller cells at high velocity, while no obvious difference along fluid velocity was observed with cultured SP2/0 tumor cells.
KW - Circulating tumor cells
KW - Deterministic lateral displacement
KW - Microfluidic device
UR - http://www.scopus.com/inward/record.url?scp=84941627714&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84941627714
T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
SP - 600
EP - 602
BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PB - Chemical and Biological Microsystems Society
T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Y2 - 26 October 2014 through 30 October 2014
ER -