Microfluidic device for capturing circulating tumor cells - Separation by cell size and rigidity

Tomoki Konishi, Hiromasa Okano, Takahiro Suzuki, Shinya Ariyasu, Toshihiro Suzuki, Ryo Abe, Shin Aoki, Masanori Hayase

研究成果: Conference contribution査読

抄録

Effect of fluid velocity on cell size sorting by a deterministic lateral displacement (DLD) device was studied. Circulating tumor cells (CTCs) tends to be larger compared to benign blood cells, and DLD sorting devices have been studied for CTC separation. However, high separation efficiency is not expected by only size sorting. We focused on cell deformability, and effect of fluid velocity on separation behavior in a simple DLD device was observed. It was found that benign lymphocytes tends to behave like smaller cells at high velocity, while no obvious difference along fluid velocity was observed with cultured SP2/0 tumor cells.

本文言語English
ホスト出版物のタイトル18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
出版社Chemical and Biological Microsystems Society
ページ600-602
ページ数3
ISBN(電子版)9780979806476
出版ステータスPublished - 1 1月 2014
イベント18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
継続期間: 26 10月 201430 10月 2014

出版物シリーズ

名前18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
国/地域United States
CitySan Antonio
Period26/10/1430/10/14

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