Irradiation effect of a submillimeter wave from 420 GHz gyrotron on amyloid peptides in vitro

Takayasu Kawasaki, Yuusuke Yamaguchi, Tomomi Ueda, Yuya Ishikawa, Toyonari Yaji, Toshiaki Ohta, Koichi Tsukiyama, Toshitaka Idehara, Masatoshi Saiki, Masahiko Tani

研究成果: Article査読

抄録

On using the far-infrared radiation system, whether the irradiation effect is thermal or non-thermal is controversial. We irradiated amyloid peptides that are causal factors for amyloidosis by using a submillimeter wave from 420 GHz gyrotron. Fluorescence reagent assay, optical and electron microscopies, and synchrotron-radiation infrared microscopy showed that the irradiation increased the fibrous conformation of peptides at room temperature for 30 min. The temperature increase on the sample was only below 5 K, and a simple heating up to 318 K hardly induced the fibril formation. Therefore, the amyloid aggregation was driven by the far-infrared radiation with little thermal effect.

本文言語English
ページ(範囲)5341-5351
ページ数11
ジャーナルBiomedical Optics Express
11
9
DOI
出版ステータスPublished - 2021

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