Highly oxygenated antiausterity agents from the leaves of Uvaria dac

Suresh Awale; Ahmed M. Tawila; Dya Fita Dibwe; Jun ya Ueda; Sijia Sun; Sirivan Athikomkulchai; Chandrashaker Balachandran; Ikuo Saiki; Kinzo Matsumoto; Hiroyasu Esumi

doi:10.1016/j.bmcl.2017.03.021

Highly oxygenated antiausterity agents from the leaves of Uvaria dac

Suresh Awale, Ahmed M. Tawila, Dya Fita Dibwe, Jun ya Ueda, Sijia Sun, Sirivan Athikomkulchai, Chandrashaker Balachandran, Ikuo Saiki, Kinzo Matsumoto, Hiroyasu Esumi

生命医科学研究所

研究成果: Article › 査読

15 被引用数 (Scopus)

抄録

From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC₅₀, 20.1 μM), PSN-1 (PC₅₀, 9.7 μM), MIA PaCa-2 (PC₅₀, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM).

本文言語	English
ページ（範囲）	1967-1971
ページ数	5
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	27
号	9
DOI	https://doi.org/10.1016/j.bmcl.2017.03.021
出版ステータス	Published - 2017

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@article{e518e70cbbf14fd0bd9619d0c680f754,

title = "Highly oxygenated antiausterity agents from the leaves of Uvaria dac",

abstract = "From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM).",

keywords = "Antiausterity agents, PANC-1, Pancreatic cancer, Preferential cytotoxicity, Uvaria dac",

author = "Suresh Awale and Tawila, {Ahmed M.} and Dibwe, {Dya Fita} and Ueda, {Jun ya} and Sijia Sun and Sirivan Athikomkulchai and Chandrashaker Balachandran and Ikuo Saiki and Kinzo Matsumoto and Hiroyasu Esumi",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research (16K08319) from the Japan Society for the Promotion of Science (JSPS), and the President's discretionary grant (# 011910) for the promotion of priority research areas from the University of Toyama. Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.bmcl.2017.03.021",

language = "English",

volume = "27",

pages = "1967--1971",

journal = "Bioorganic and Medicinal Chemistry Letters",

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AU - Awale, Suresh

AU - Tawila, Ahmed M.

AU - Dibwe, Dya Fita

AU - Ueda, Jun ya

AU - Sun, Sijia

AU - Athikomkulchai, Sirivan

AU - Balachandran, Chandrashaker

AU - Saiki, Ikuo

AU - Matsumoto, Kinzo

AU - Esumi, Hiroyasu

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research (16K08319) from the Japan Society for the Promotion of Science (JSPS), and the President's discretionary grant (# 011910) for the promotion of priority research areas from the University of Toyama. Publisher Copyright: © 2017 Elsevier Ltd

PY - 2017

Y1 - 2017

N2 - From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM).

AB - From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM).

KW - Antiausterity agents

KW - PANC-1

KW - Pancreatic cancer

KW - Preferential cytotoxicity

KW - Uvaria dac

UR - http://www.scopus.com/inward/record.url?scp=85015942234&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2017.03.021

DO - 10.1016/j.bmcl.2017.03.021

M3 - Article

C2 - 28342587

AN - SCOPUS:85015942234

SN - 0960-894X

VL - 27

SP - 1967

EP - 1971

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

Highly oxygenated antiausterity agents from the leaves of Uvaria dac

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