Functionalization and Magnetic Relaxation of Ferrite Nanoparticles for Theranostics

Daiki Shigeoka; Takahiro Yamazaki; Tomoya Ishikawa; Kazunari Miike; Koki Fujiwara; Taisei Ide; Akito Oshima; Tatsuya Hashimoto; Daiki Aihara; Kouhei Kanda; Akihito Usui; Yoshiyuki Hosokai; Haruo Saito; Yuko Ichiyanagi

doi:10.1109/TMAG.2018.2845132

Functionalization and Magnetic Relaxation of Ferrite Nanoparticles for Theranostics

Daiki Shigeoka, Takahiro Yamazaki, Tomoya Ishikawa, Kazunari Miike, Koki Fujiwara, Taisei Ide, Akito Oshima, Tatsuya Hashimoto, Daiki Aihara, Kouhei Kanda, Akihito Usui, Yoshiyuki Hosokai, Haruo Saito, Yuko Ichiyanagi

総合研究院

研究成果: Article › 査読

12 被引用数 (Scopus)

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Magnetic nanoparticles have drawn attention recently due to their interesting nanoscopic features and potential applications. Various kinds of ferrite nanoparticles with diameters between 3 and 34 nm encapsulated by amorphous SiO₂ were functionalized and examined for biomedical applications. From dc and ac magnetic susceptibility measurements, it was found that these particles followed the Néel relaxation system. Co-Zn ferrite (Co_0.8Zn_0.2Fe₂O₄) nanoparticles were prepared and the increase in temperature in the ac field was estimated for hyperthermia treatment. In vitro experiments using cultured human breast cancer cells were carried out, and a dramatic hyperthermia effect was observed. As one of the diagnostic methods, magnetic resonance (MR) measurements were performed for CoFe₂O₄ nanoparticles, and the samples were also evaluated as potential contrast media for MR imaging.

本文言語	English
論文番号	8411164
ジャーナル	IEEE Transactions on Magnetics
巻	54
号	11
DOI	https://doi.org/10.1109/TMAG.2018.2845132
出版ステータス	Published - 2018

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10.1109/TMAG.2018.2845132

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title = "Functionalization and Magnetic Relaxation of Ferrite Nanoparticles for Theranostics",

abstract = "Magnetic nanoparticles have drawn attention recently due to their interesting nanoscopic features and potential applications. Various kinds of ferrite nanoparticles with diameters between 3 and 34 nm encapsulated by amorphous SiO2 were functionalized and examined for biomedical applications. From dc and ac magnetic susceptibility measurements, it was found that these particles followed the N{\'e}el relaxation system. Co-Zn ferrite (Co0.8Zn0.2Fe2O4) nanoparticles were prepared and the increase in temperature in the ac field was estimated for hyperthermia treatment. In vitro experiments using cultured human breast cancer cells were carried out, and a dramatic hyperthermia effect was observed. As one of the diagnostic methods, magnetic resonance (MR) measurements were performed for CoFe2O4 nanoparticles, and the samples were also evaluated as potential contrast media for MR imaging.",

keywords = "Magnetic particles, magnetic susceptibility, medical diagnostic imaging, nanoparticles",

author = "Daiki Shigeoka and Takahiro Yamazaki and Tomoya Ishikawa and Kazunari Miike and Koki Fujiwara and Taisei Ide and Akito Oshima and Tatsuya Hashimoto and Daiki Aihara and Kouhei Kanda and Akihito Usui and Yoshiyuki Hosokai and Haruo Saito and Yuko Ichiyanagi",

note = "Publisher Copyright: {\textcopyright} 1965-2012 IEEE.",

year = "2018",

doi = "10.1109/TMAG.2018.2845132",

language = "English",

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journal = "IEEE Transactions on Magnetics",

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T1 - Functionalization and Magnetic Relaxation of Ferrite Nanoparticles for Theranostics

AU - Shigeoka, Daiki

AU - Yamazaki, Takahiro

AU - Ishikawa, Tomoya

AU - Miike, Kazunari

AU - Fujiwara, Koki

AU - Ide, Taisei

AU - Oshima, Akito

AU - Hashimoto, Tatsuya

AU - Aihara, Daiki

AU - Kanda, Kouhei

AU - Usui, Akihito

AU - Hosokai, Yoshiyuki

AU - Saito, Haruo

AU - Ichiyanagi, Yuko

PY - 2018

Y1 - 2018

N2 - Magnetic nanoparticles have drawn attention recently due to their interesting nanoscopic features and potential applications. Various kinds of ferrite nanoparticles with diameters between 3 and 34 nm encapsulated by amorphous SiO2 were functionalized and examined for biomedical applications. From dc and ac magnetic susceptibility measurements, it was found that these particles followed the Néel relaxation system. Co-Zn ferrite (Co0.8Zn0.2Fe2O4) nanoparticles were prepared and the increase in temperature in the ac field was estimated for hyperthermia treatment. In vitro experiments using cultured human breast cancer cells were carried out, and a dramatic hyperthermia effect was observed. As one of the diagnostic methods, magnetic resonance (MR) measurements were performed for CoFe2O4 nanoparticles, and the samples were also evaluated as potential contrast media for MR imaging.

AB - Magnetic nanoparticles have drawn attention recently due to their interesting nanoscopic features and potential applications. Various kinds of ferrite nanoparticles with diameters between 3 and 34 nm encapsulated by amorphous SiO2 were functionalized and examined for biomedical applications. From dc and ac magnetic susceptibility measurements, it was found that these particles followed the Néel relaxation system. Co-Zn ferrite (Co0.8Zn0.2Fe2O4) nanoparticles were prepared and the increase in temperature in the ac field was estimated for hyperthermia treatment. In vitro experiments using cultured human breast cancer cells were carried out, and a dramatic hyperthermia effect was observed. As one of the diagnostic methods, magnetic resonance (MR) measurements were performed for CoFe2O4 nanoparticles, and the samples were also evaluated as potential contrast media for MR imaging.

KW - Magnetic particles

KW - magnetic susceptibility

KW - medical diagnostic imaging

KW - nanoparticles

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DO - 10.1109/TMAG.2018.2845132

M3 - Article

AN - SCOPUS:85049967910

SN - 0018-9464

VL - 54

JO - IEEE Transactions on Magnetics

JF - IEEE Transactions on Magnetics

IS - 11

M1 - 8411164

ER -

Functionalization and Magnetic Relaxation of Ferrite Nanoparticles for Theranostics

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