Fluorogenically active leucine zipper peptides as tag-probe pairs for protein imaging in living cells

Hiroshi Tsutsumi, Wataru Nomura, Seiichiro Abe, Tomoaki Mino, Akemi Masuda, Nami Ohashi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Kazunari Akiyoshi, Hirokazu Tamamura

研究成果: Article査読

27 被引用数 (Scopus)

抄録

All zipped up: Pairs of leucine zipper peptides with a solvatochromic fluorescent dye show fluorogenic activity through formation of a 3α-helical bundle structure. Such peptides enable the in situ fluores-cence imaging of proteins in the presence of excess fluorescent probe (see picture). Imaging of membrane-bound protein is demonstrated using these zipper peptides as functional tag-probe pairs.

本文言語English
ページ(範囲)9164-9166
ページ数3
ジャーナルAngewandte Chemie - International Edition
48
48
DOI
出版ステータスPublished - 16 11月 2009

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