Facile and diastereoselective synthesis of 3,2′-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities

D. Kathirvelan; J. Haribabu; B. S.R. Reddy; C. Balachandran; V. Duraipandiyan

doi:10.1016/j.bmcl.2014.10.099

Facile and diastereoselective synthesis of 3,2′-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities

D. Kathirvelan, J. Haribabu, B. S.R. Reddy, C. Balachandran, V. Duraipandiyan

生命医科学研究所

研究成果: Article › 査読

82 被引用数 (Scopus)

抄録

In the present study, a series of novel highly functionalized spiropyrrolidine-oxindoles have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide formed from isatin and various amino acids such as sarcosine, proline and thioproline with the dipolarophile (E)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile under optimized conditions. All the synthesized compounds were evaluated for their antimicrobial activity and shown significant activity.

本文言語	English
ページ（範囲）	389-399
ページ数	11
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	25
号	2
DOI	https://doi.org/10.1016/j.bmcl.2014.10.099
出版ステータス	Published - 15 1月 2015

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10.1016/j.bmcl.2014.10.099

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引用スタイル

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abstract = "In the present study, a series of novel highly functionalized spiropyrrolidine-oxindoles have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide formed from isatin and various amino acids such as sarcosine, proline and thioproline with the dipolarophile (E)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile under optimized conditions. All the synthesized compounds were evaluated for their antimicrobial activity and shown significant activity.",

keywords = "Antimicrobial activity, Molecular docking, Multicomponent reaction, Pyrazole moiety, Spirooxindole",

author = "D. Kathirvelan and J. Haribabu and Reddy, {B. S.R.} and C. Balachandran and V. Duraipandiyan",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd.",

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AU - Reddy, B. S.R.

AU - Balachandran, C.

AU - Duraipandiyan, V.

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KW - Molecular docking

KW - Multicomponent reaction

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