Fabrication and characterization of silicon nitride directional coupler interferometer for sensing aptamer hybridization

K. Okubo, K. Uchiyamada, M. Yokokawa, K. Asakawa, H. Suzuki

研究成果: Conference contribution査読

抄録

We used silicon nitride (Si3N4) directional coupler (DC) interferometers to fabricate evanescent field biosensors for detection of aptamer hybridization. The DC detects temporal changes in refractive index (RI) as changes in the relative intensities of near-fields. Numerical simulation provided information for sensitivity of the DC as well as preferable dimensions of single mode waveguides. The result suggests that lengthening the DC improves its sensitivity. Another approach to realize high sensitivity was to make the coupling region of the DC longer for a given complete coupling length Lc. A folded DC is also presented based on calculations using Si waveguides. Here a meander-line with an array of segmented DCs and asymmetric 180°-curved waveguides was accommodated in a (100 μm)2 square area. Phases of propagating lights within two curved waveguides could be coincided. This cascade-connection of the segments of the DCs facilitated highly sensitive detection of biomolecules and a flexible sensor design. Signal dependences on device length and bulk RI change were evaluated by end-fire coupling measurements. The optical intensities agreed well with the corresponding fitting curve and the curve calculated based on the coupled mode theory.

本文言語English
ホスト出版物のタイトルFrontiers in Biological Detection
ホスト出版物のサブタイトルFrom Nanosensors to Systems VIII
編集者Sharon M. Weiss, Amos Danielli, G. Logan Liu, Benjamin L. Miller, Brian T. Cunningham
出版社SPIE
ISBN(電子版)9781628419597
DOI
出版ステータスPublished - 2016
イベントFrontiers in Biological Detection: From Nanosensors to Systems VIII - San Francisco, United States
継続期間: 14 2月 201615 2月 2016

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
9725
ISSN(印刷版)1605-7422

Conference

ConferenceFrontiers in Biological Detection: From Nanosensors to Systems VIII
国/地域United States
CitySan Francisco
Period14/02/1615/02/16

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