Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles

Takunori Harada, Hiraku Matsuzaki, Ryohei Oyama, Takuma Takeuchi, Tomoaki Takei, Taisuke Ninomiya, Kouta Takami, Takanori Inoue, Hiroyasu Nishiguchi, Emi Hifumi, Hiroyuki Shinto, Hiromi Takahashi, Kazuo Umemura

研究成果: Article

抜粋

We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen product 1O2 close to the amyloid superstructures, resulting in AF decomposition.

元の言語English
ページ(範囲)29-33
ページ数5
ジャーナルPhotochemical and Photobiological Sciences
19
発行部数1
DOI
出版物ステータスPublished - 1 1 2020

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これを引用

Harada, T., Matsuzaki, H., Oyama, R., Takeuchi, T., Takei, T., Ninomiya, T., Takami, K., Inoue, T., Nishiguchi, H., Hifumi, E., Shinto, H., Takahashi, H., & Umemura, K. (2020). Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles. Photochemical and Photobiological Sciences, 19(1), 29-33. https://doi.org/10.1039/c9pp00356h