Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins

Tetsuo Narumi, Mao Komoriya, Chie Hashimoto, Honggui Wu, Wataru Nomura, Shintaro Suzuki, Tomohiro Tanaka, Joe Chiba, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Compounds which inhibit the HIV-1 replication cycle have been found amongst fragment peptides derived from an HIV-1 matrix (MA) protein. Overlapping peptide libraries covering the whole sequence of MA were designed and constructed with the addition of an octa-arginyl group to increase their cell membrane permeability. Imaging experiments with fluorescent-labeled peptides demonstrated these peptides with an octa-arginyl group can penetrate cell membranes. The fusion of an octa-arginyl group was proven to be an efficient way to find active peptides in cells such as HIV-inhibitory peptides.

本文言語English
ページ(範囲)1468-1474
ページ数7
ジャーナルBioorganic and Medicinal Chemistry
20
4
DOI
出版ステータスPublished - 15 2月 2012

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