C/EBPα controls mast cell function

Kazumi Kasakura; Kyoko Takahashi; Tomoko Itoh; Akira Hosono; Satoshi Nunomura; Chisei Ra; Yoshika Momose; Kikuji Itoh; Chiharu Nishiyama; Shuichi Kaminogawa

doi:10.1016/j.febslet.2014.10.036

C/EBPα controls mast cell function

Kazumi Kasakura, Kyoko Takahashi, Tomoko Itoh, Akira Hosono, Satoshi Nunomura, Chisei Ra, Yoshika Momose, Kikuji Itoh, Chiharu Nishiyama, Shuichi Kaminogawa

生命システム工学科

研究成果: Article › 査読

15 被引用数 (Scopus)

抄録

CCAAT/enhancer binding protein alpha (C/EBPα) is a transcription factor that influences immune cell fate and differentiation. However, the effect of C/EBPα on mast cells is not fully understood. In this study, we showed that C/EBPα suppressed granule formation in mast cells and increased macrophage inflammatory protein (MIP)-2 production from mast cells upon bacterial stimulation. These results indicate that C/EBPα regulates the balance between the allergic response and the innate immune response of mast cells. Furthermore, we showed that stimulation of mast cells with the Lactobacillus casei JCM1134^T strain during late differentiation up-regulated C/EBPα expression in differentiated mast cells. This suggests that intestinal commensal bacteria modulate C/EBPα expression and thereby regulate mast cell function.

本文言語	English
ページ（範囲）	4645-4653
ページ数	9
ジャーナル	FEBS Letters
巻	588
号	24
DOI	https://doi.org/10.1016/j.febslet.2014.10.036
出版ステータス	Published - 20 12月 2014

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10.1016/j.febslet.2014.10.036

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title = "C/EBPα controls mast cell function",

abstract = "CCAAT/enhancer binding protein alpha (C/EBPα) is a transcription factor that influences immune cell fate and differentiation. However, the effect of C/EBPα on mast cells is not fully understood. In this study, we showed that C/EBPα suppressed granule formation in mast cells and increased macrophage inflammatory protein (MIP)-2 production from mast cells upon bacterial stimulation. These results indicate that C/EBPα regulates the balance between the allergic response and the innate immune response of mast cells. Furthermore, we showed that stimulation of mast cells with the Lactobacillus casei JCM1134T strain during late differentiation up-regulated C/EBPα expression in differentiated mast cells. This suggests that intestinal commensal bacteria modulate C/EBPα expression and thereby regulate mast cell function.",

keywords = "Allergy, CCAAT/enhancer binding protein alpha, Commensal bacteria, Innate immunity, Mast cell, Terminal differentiation",

author = "Kazumi Kasakura and Kyoko Takahashi and Tomoko Itoh and Akira Hosono and Satoshi Nunomura and Chisei Ra and Yoshika Momose and Kikuji Itoh and Chiharu Nishiyama and Shuichi Kaminogawa",

year = "2014",

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doi = "10.1016/j.febslet.2014.10.036",

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T1 - C/EBPα controls mast cell function

AU - Kasakura, Kazumi

AU - Takahashi, Kyoko

AU - Itoh, Tomoko

AU - Hosono, Akira

AU - Nunomura, Satoshi

AU - Ra, Chisei

AU - Momose, Yoshika

AU - Itoh, Kikuji

AU - Nishiyama, Chiharu

AU - Kaminogawa, Shuichi

PY - 2014/12/20

Y1 - 2014/12/20

N2 - CCAAT/enhancer binding protein alpha (C/EBPα) is a transcription factor that influences immune cell fate and differentiation. However, the effect of C/EBPα on mast cells is not fully understood. In this study, we showed that C/EBPα suppressed granule formation in mast cells and increased macrophage inflammatory protein (MIP)-2 production from mast cells upon bacterial stimulation. These results indicate that C/EBPα regulates the balance between the allergic response and the innate immune response of mast cells. Furthermore, we showed that stimulation of mast cells with the Lactobacillus casei JCM1134T strain during late differentiation up-regulated C/EBPα expression in differentiated mast cells. This suggests that intestinal commensal bacteria modulate C/EBPα expression and thereby regulate mast cell function.

AB - CCAAT/enhancer binding protein alpha (C/EBPα) is a transcription factor that influences immune cell fate and differentiation. However, the effect of C/EBPα on mast cells is not fully understood. In this study, we showed that C/EBPα suppressed granule formation in mast cells and increased macrophage inflammatory protein (MIP)-2 production from mast cells upon bacterial stimulation. These results indicate that C/EBPα regulates the balance between the allergic response and the innate immune response of mast cells. Furthermore, we showed that stimulation of mast cells with the Lactobacillus casei JCM1134T strain during late differentiation up-regulated C/EBPα expression in differentiated mast cells. This suggests that intestinal commensal bacteria modulate C/EBPα expression and thereby regulate mast cell function.

KW - Allergy

KW - CCAAT/enhancer binding protein alpha

KW - Commensal bacteria

KW - Innate immunity

KW - Mast cell

KW - Terminal differentiation

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U2 - 10.1016/j.febslet.2014.10.036

DO - 10.1016/j.febslet.2014.10.036

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C2 - 25447519

AN - SCOPUS:84915746327

SN - 0014-5793

VL - 588

SP - 4645

EP - 4653

JO - FEBS Letters

JF - FEBS Letters

IS - 24

ER -

C/EBPα controls mast cell function

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