Carbon ion beam radioresistant rodent cells are sensitized to trifluorothymidine exposure

Sung Jae Baek, Katsutoshi Sato, Naohiro Nishida, Jun Koseki, Kazuhiko Hayashi, Koichi Kawamoto, Masamitsu Konno, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa, Hideshi Ishii

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Although charged particle therapy, including carbon ion beam radiation, is a cutting-edge technology in human cancer treatment, the molecular mechanisms underlying cellular resistance to this type of therapy remain unknown. Furthermore, the chemotherapeutic agents that are most effective at overcoming cellular resistance remain unknown. In the present study, carbon ion beam radioresistant rodent cells were developed and their sensitization to trifluorothymidine (FTD), a derivative of deoxythymidine, was studied. The results of the present study demonstrated that carbon ion beam radioresistant cells were more sensitive to FTD compared with X-ray radioresistant cells. The results of the present study suggested that FTD is involved in carbon ion beam radioresistance, encouraging further study of cellular resistance to charged particle therapy for refractory human cancer.

本文言語English
ページ(範囲)3389-3393
ページ数5
ジャーナルOncology Letters
16
3
DOI
出版ステータスPublished - 9月 2018

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