TY - JOUR
T1 - Antimicrobial and Antimycobacterial Activities of Methyl Caffeate Isolated from Solanum torvum Swartz. Fruit
AU - Balachandran, Chandrasekhar
AU - Duraipandiyan, Veeramuthu
AU - Al-Dhabi, Naif Abdullah
AU - Balakrishna, K.
AU - Kalia, Nitin Pal
AU - Rajput, Vikrant Singh
AU - Khan, Inshad Ali
AU - Ignacimuthu, Savarimuthu
N1 - Funding Information:
Acknowledgments We thank R. Lakshmi Sundaram, Application Specialist, Central Research Facility, Sri Ramachandra University, for helping in spectroscopy. We are grateful to OSDD-CSIR, New Delhi and Entomology Research Institute, Chennai, for financial assistance.
PY - 2012/12
Y1 - 2012/12
N2 - Solanum torvum Swartz. (Solanaceae) fruit is traditionally used for the treatment of bacterial and fungal infections. The methanolic extract was subjected to activity guided fractionation by column chromatography over silica gel. The structure of the compound was elucidated using physical and spectroscopic data. The antimicrobial activity was screened using five Gram-positive bacteria, six Gram-negative bacteria, seven clinical isolates and four fungi. Antimycobacterial activity was screened against two Mycobacterium strains. The zone of inhibition by methyl caffeate ranged from 0 to 22 mm. The lowest minimum inhibitory concentration (MIC) values of methyl caffeate were: 50 μg/ml against P. vulgaris, 25 μg/ml against K. pneumoniae (ESBL-3971), 8 μg/ml against M. tuberculosis (H37Rv) and 8 μg/ml against M. tuberculosis (RifR). Methyl caffeate showed moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate can be evaluated further for drug development.
AB - Solanum torvum Swartz. (Solanaceae) fruit is traditionally used for the treatment of bacterial and fungal infections. The methanolic extract was subjected to activity guided fractionation by column chromatography over silica gel. The structure of the compound was elucidated using physical and spectroscopic data. The antimicrobial activity was screened using five Gram-positive bacteria, six Gram-negative bacteria, seven clinical isolates and four fungi. Antimycobacterial activity was screened against two Mycobacterium strains. The zone of inhibition by methyl caffeate ranged from 0 to 22 mm. The lowest minimum inhibitory concentration (MIC) values of methyl caffeate were: 50 μg/ml against P. vulgaris, 25 μg/ml against K. pneumoniae (ESBL-3971), 8 μg/ml against M. tuberculosis (H37Rv) and 8 μg/ml against M. tuberculosis (RifR). Methyl caffeate showed moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate can be evaluated further for drug development.
KW - Antimicrobial
KW - Antimycobacterial
KW - Methyl caffeate
KW - Solanum torvum
UR - http://www.scopus.com/inward/record.url?scp=84870824099&partnerID=8YFLogxK
U2 - 10.1007/s12088-012-0313-8
DO - 10.1007/s12088-012-0313-8
M3 - Article
AN - SCOPUS:84870824099
SN - 0046-8991
VL - 52
SP - 676
EP - 681
JO - Indian Journal of Microbiology
JF - Indian Journal of Microbiology
IS - 4
ER -