@article{43115fe920154328bf71d2f5a545e73e,
title = "An easy protocol for the domino synthesis of diversely functionalized spirocarbocycles and their biological evaluation",
abstract = "A base-catalysed domino reaction for the synthesis of spirocarbocycles in excellent yields using chalcones and vinyl malononitriles is reported. This consists of a series of steps including Knoevenagel condensation followed by intermolecular vinylogous Michael addition and intramolecular cyclization. The synthesized compounds were evaluated for their antimicrobial activity and the compounds exhibited moderate to excellent activities.",
keywords = "Antimicrobial activity., Chalcones, L-proline, Spirocarbocycles, Vinyl malononitriles",
author = "Kiruthika, {Selvarangam E.} and Perumal, {Paramasivan T.} and C. Balachandran and S. Ignacimuthu",
note = "Funding Information: SEK thanks the Council of Scientific and Industrial Research (CSIR), New Delhi, India for the research fellowship. We also thank Department of Chemistry, Indian Institute of Technology, Madras for X-ray single crystal analysis.",
year = "2014",
month = jan,
doi = "10.1007/s12039-013-0560-1",
language = "English",
volume = "126",
pages = "177--185",
journal = "Journal of Chemical Sciences",
issn = "0974-3626",
publisher = "Indian Academy of Sciences",
number = "1",
}