An anti-tumorigenic role of the warburg effect at emergence of transformed cells

Kojiro Ishibashi, Riku Egami, Kazuki Nakai, Shunsuke Kon

研究成果: Short survey査読

2 被引用数 (Scopus)

抄録

The Warburg effect is one of the hallmarks of cancer cells, characterized by enhanced aerobic glycolysis. Despite intense research efforts, its functional relevance or biological significance to facilitate tumor progression is still debatable. Hence the question persists when and how the Warburg effect contributes to carcinogenesis. Especially, the role of metabolic changes at a very early stage of tumorigenesis has received relatively little attention, and how aerobic glycolysis impacts tumor incidence remains largely unknown. Here we discuss a novel paradigm for the effect of the Warburg effect that provides a suppressive role in oncogenesis.

本文言語English
ページ(範囲)171-176
ページ数6
ジャーナルCell structure and function
43
2
DOI
出版ステータスPublished - 2018

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