A humoral stress response protects Drosophila tissues from antimicrobial peptides

Samuel Rommelaere, Alexia Carboni, Juan F. Bada Juarez, Jean Philippe Boquete, Luciano A. Abriata, Fernando Teixeira Pinto Meireles, Verena Rukes, Crystal Vincent, Shu Kondo, Marc S. Dionne, Matteo Dal Peraro, Chan Cao, Bruno Lemaitre

研究成果: Article査読

3 被引用数 (Scopus)

抄録

7An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host from its own immune response. Antimicrobial peptides (AMPs) are small, cationic peptides that contribute to innate defenses by targeting negatively charged membranes of microbes. While protective against pathogens, AMPs can be cytotoxic to host cells. Here, we reveal that a family of stress-induced proteins, the Turandots, protect the Drosophila respiratory system from AMPs, increasing resilience to stress. Flies lacking Turandot genes are susceptible to environmental stresses due to AMP-induced tracheal apoptosis. Turandot proteins bind to host cell membranes and mask negatively charged phospholipids, protecting them from cationic pore-forming AMPs. Collectively, these data demonstrate that Turandot stress proteins mitigate AMP cytotoxicity to host tissues and therefore improve their efficacy.

本文言語English
ページ(範囲)1426-1437.e6
ジャーナルCurrent Biology
34
7
DOI
出版ステータスPublished - 8 4月 2024

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