Akira Sato

2022

Passion fruit seed extract protects beta-amyloid-induced neuronal cell death in a differentiated human neuroblastoma SH-SY5Y cell model

Sato, A., Tagai, N., Ogino, Y., Uozumi, H., Kawakami, S., Yamamoto, T., Tanuma, S. I., Maruki-Uchida, H., Mori, S. & Morita, M., 5月 2022, In: Food Science and Nutrition. 10, 5, p. 1461-1468 8 p.

研究成果: Article › 査読

Open Access

Trapping of 5-Fluorodeoxyuridine Monophosphate by Thymidylate Synthase Confers Resistance to 5-Fluorouracil

Kurasaka, C., Nishizawa, N., Ogino, Y. & Sato, A., 22 2月 2022, In: ACS Omega. 7, 7, p. 6046-6052 7 p.

研究成果: Article › 査読

Open Access

2021

Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain

Yoshizawa, K., Takeuchi, K., Nakamura, T., Ukai, S., Takahashi, Y., Sato, A., Takasawa, R. & Tanuma, S. I., 3月 2021, In: Synapse. 75, 3, e22188.

研究成果: Article › 査読

2 被引用数 (Scopus)

Human microRNA hsa-miR-15b-5p targets the RNA template component of the RNA-dependent RNA polymerase structure in severe acute respiratory syndrome coronavirus 2

Sato, A., Ogino, Y., Tanuma, S. I. & Uchiumi, F., 2021, In: Nucleosides, Nucleotides and Nucleic Acids. 40, 8, p. 790-797 8 p.

研究成果: Article › 査読

Molecular mechanisms and tumor biological aspects of 5-fluorouracil resistance in hct116 human colorectal cancer cells

Kurasaka, C., Ogino, Y. & Sato, A., 2 3月 2021, In: International journal of molecular sciences. 22, 6, p. 1-15 15 p., 2916.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages

Ogawa, N., Nakajima, S., Tamada, K., Yokoue, N., Tachibana, H., Okazawa, M., Oyama, T., Abe, H., Yamazaki, H., Yoshimori, A., Sato, A., Kamiya, T., Yokomizo, T., Uchiumi, F., Abe, T. & Tanuma, S. I., 30 10月 2021, In: Archives of Biochemistry and Biophysics. 711, 109029.

研究成果: Article › 査読

1 被引用数 (Scopus)

2020

Direct interaction analysis of microRNA-351-5p and nuclear scaffold lamin B1 mRNA by the cell-free in vitro mRNA/miRNA binding evaluation system

Sato, A., Ogino, Y., Shimotsuma, A., Hiramoto, A., Kim, H. S. & Wataya, Y., 2 6月 2020, In: Nucleosides, Nucleotides and Nucleic Acids. 39, 6, p. 799-805 7 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Intracellular microRNA expression patterns influence cell death fates for both necrosis and apoptosis

Sato, A., Yamamoto, A., Shimotsuma, A., Ogino, Y., Funayama, N., Takahashi, Y., Hiramoto, A., Wataya, Y. & Kim, H. S., 1 11月 2020, In: FEBS Open Bio. 10, 11, p. 2417-2426 10 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Low levels of brain-derived neurotrophic factor trigger self-aggregated amyloid β-induced neuronal cell death in an Alzheimer's cell model

Tagai, N., Tanaka, A., Sato, A., Uchiumi, F. & Tanuma, S. I., 1 7月 2020, In: Biological and Pharmaceutical Bulletin. 43, 7, p. 1073-1080 8 p.

研究成果: Article › 査読

Open Access

6 被引用数 (Scopus)

Structural basis of beneficial design for effective nicotinamide phosphoribosyltransferase inhibitors

Tanuma, S. I., Katsuragi, K., Oyama, T., Yoshimori, A., Shibasaki, Y., Asawa, Y., Yamazaki, H., Makino, K., Okazawa, M., Ogino, Y., Sakamoto, Y., Nomura, M., Sato, A., Abe, H., Nakamura, H., Takahashi, H., Tanuma, N. & Uchiumi, F., 8月 2020, In: Molecules. 25, 16, 3633.

研究成果: Article › 査読

Open Access

5 被引用数 (Scopus)

Trimebutine attenuates high mobility group box 1–receptor for advanced glycation end-products inflammatory signaling pathways

Nakajima, S., Ogawa, N., Yokoue, N., Tachibana, H., Tamada, K., Okazawa, M., Sato, A., Oyama, T., Abe, H., Kamiya, T., Yoshimori, A., Yoshizawa, K., Inoue, S., Yokomizo, T., Uchiumi, F., Abe, T. & Tanuma, S. I., 17 12月 2020, In: Biochemical and Biophysical Research Communications. 533, 4, p. 1155-1161 7 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

2019

Anticancer effects of a non-narcotic opium alkaloid medicine, papaverine, in human glioblastoma cells

Inada, M., Shindo, M., Kobayashi, K., Sato, A., Yamamoto, Y., Akasaki, Y., Ichimura, K. & Tanuma, S. I., 5月 2019, In: PloS one. 14, 5, e0216358.

研究成果: Article › 査読

Open Access

22 被引用数 (Scopus)

Anticancer non-narcotic opium alkaloid papaverine suppresses human glioblastoma cell growth

Inada, M., Sato, A., Shindo, M., Yamamoto, Y., Akasaki, Y., Ichimura, K. & Tanuma, S. I., 2019, In: Anticancer research. 39, 12, p. 6743-6749 7 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Association of ABC transporter with resistance to FK866, a NAMPT inhibitor, in human colorectal cancer cells

Ogino, Y., Sato, A., Kawano, Y., Aoyama, T., Uchiumi, F. & Tanuma, S. I., 2019, In: Anticancer research. 39, 12, p. 6457-6462 6 p.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy

Tsugawa, H., Mori, H., Matsuzaki, J., Sato, A., Saito, Y., Imoto, M., Suematsu, M. & Suzuki, H., 1 2月 2019, In: Autophagy. 15, 2, p. 242-258 17 p.

研究成果: Article › 査読

17 被引用数 (Scopus)

Characterization of the human E2F4 promoter region and its response to 12-O-tetradecanoylphorbol-13-acetate

Hamada, H., Goto, Y., Arakawa, J., Murayama, E., Ogawa, Y., Konno, M., Oyama, T., Asai, M., Sato, A., Tanuma, S. I. & Uchiumi, F., 15 8月 2019, In: Journal of Infectious Diseases. 220, 4, p. 363-373 11 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth

Yamamoto, T., Sato, A., Takai, Y., Yoshimori, A., Umehara, M., Ogino, Y., Inada, M., Shimada, N., Nishida, A., Ichida, R., Takasawa, R., Maruki-Uchida, H., Mori, S., Sai, M., Morita, M. & Tanuma, S. I., 12月 2019, In: Biochemistry and Biophysics Reports. 20, 100684.

研究成果: Article › 査読

Open Access

9 被引用数 (Scopus)

Genomic and biological features of Plasmodium falciparum resistance against antimalarial endoperoxide N-89

Morita, M., Hayashi, K., Sato, A., Hiramoto, A., Kaneko, O., Isogawa, R., Kurosaki, Y., Miyoshi, S. I., Chang, K. S., Wataya, Y. & Kim, H. S., 20 10月 2019, In: Gene. 716, 144016.

研究成果: Article › 査読

2 被引用数 (Scopus)

Genomic and tumor biological aspects of the anticancer nicotinamide phosphoribosyltransferase inhibitor FK866 in resistant human colorectal cancer cells

Ogino, Y., Sato, A., Uchiumi, F. & Tanuma, S. I., 12月 2019, In: Genomics. 111, 6, p. 1889-1895 7 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses

Tamada, K., Nakajima, S., Ogawa, N., Inada, M., Shibasaki, H., Sato, A., Takasawa, R., Yoshimori, A., Suzuki, Y., Watanabe, N., Oyama, T., Abe, H., Inoue, S., Abe, T., Yokomizo, T. & Tanuma, S., 9 4月 2019, In: Biochemical and Biophysical Research Communications. 511, 3, p. 665-670 6 p.

研究成果: Article › 査読

20 被引用数 (Scopus)

Pharmacokinetic analysis of new synthetic antimalarial N-251

Okada, K., Sato, A., Hiramoto, A., Isogawa, R., Kurosaki, Y., Higaki, K., Miyoshi, S. I., Chang, K. S. & Kim, H. S., 5 7月 2019, In: Tropical Medicine and Health. 47, 1, 40.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors

Asawa, Y., Katsuragi, K., Sato, A., Yoshimori, A., Tanuma, S. I. & Nakamura, H., 1 7月 2019, In: Bioorganic and Medicinal Chemistry. 27, 13, p. 2832-2844 13 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

2018

Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment

Ogino, Y., Sato, A., Uchiumi, F. & Tanuma, S. I., 2018, In: Oncotarget. 9, 23, p. 16451-16461 11 p.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

Insights into the mode of action of 1,2,6,7-tetraoxaspiro [7.11] nonadecane (N-89) against adult Schistosoma mansoni worms

Blay, E. A., Kumagai, T., Yamabe, M., Hino, A., Shimogawara, R., Kim, H. S., Sato, A., Ichimura, K., Ayi, I., Iwanaga, S. & Ohta, N., 8月 2018, In: Parasitology International. 67, 4, p. 403-412 10 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system

El-Far, A. H. A. M., Munesue, S., Harashima, A., Sato, A., Shindo, M., Nakajima, S., Inada, M., Tanaka, M., Takeuchi, A., Tsuchiya, H., Yamamoto, H., Shaheen, H. M. E., El-Sayed, Y. S., Kawano, S., Tanuma, S. I. & Yamamoto, Y., 4月 2018, In: Oncology Letters. 15, 4, p. 4627-4634 8 p.

研究成果: Article › 査読

Open Access

18 被引用数 (Scopus)

2017

Cationic Amphiphilic Tris-Cyclometalated Iridium(III) Complexes Induce Cancer Cell Death via Interaction with Ca²⁺-Calmodulin Complex

Hisamatsu, Y., Suzuki, N., Masum, A. A., Shibuya, A., Abe, R., Sato, A., Tanuma, S. I. & Aoki, S., 15 2月 2017, In: Bioconjugate chemistry. 28, 2, p. 507-523 17 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Novel synthetic compounds with endoperoxide structure damage juvenile stage of Schistosoma mansoni by targeting lysosome-like organelles

Yamabe, M., Kumagai, T., Shimogawara, R., Blay, E. A., Hino, A., Ichimura, K., Sato, A., Kim, H. S. & Ohta, N., 1 2月 2017, In: Parasitology International. 66, 1, p. 917-924 8 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Potential of synthetic endoperoxides against Trichomonas vaginalis in vitro

Seo, M. Y., Ryu, J. S., Sato, A., Kurosaki, Y., Chang, K. S. & Kim, H. S., 10月 2017, In: Parasitology International. 66, 5, p. 619-621 3 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Role of the uridine/cytidine kinase 2 mutation in cellular sensitiveness toward 3′-ethynylcytidine treatment of human cancer cells

Sato, A., Takano, T., Hiramoto, A., Naito, T., Matsuda, A., Fukushima, M., Wataya, Y. & Kim, H. S., 24 5月 2017, In: Anti-Cancer Drugs. 28, 7, p. 781-786 6 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Structural insight into the active site of mushroom tyrosinase using phenylbenzoic acid derivatives

Oyama, T., Yoshimori, A., Takahashi, S., Yamamoto, T., Sato, A., Kamiya, T., Abe, H., Abe, T. & Tanuma, S. I., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 13, p. 2868-2872 5 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

2016

Discovery of a new type of scaffold for the creation of novel tyrosinase inhibitors

Oyama, T., Takahashi, S., Yoshimori, A., Yamamoto, T., Sato, A., Kamiya, T., Abe, H., Abe, T. & Tanuma, S. I., 2016, In: Bioorganic and Medicinal Chemistry. 24, 18, p. 4509-4515 7 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

Establishing a screening system for new O⁶-methylguanine-DNA methyltransferase inhibitors to develop combination chemotherapy for temozolomide-resistant glioblastoma

Shindo, M., Sato, A., Yamamoto, Y., Arai, T., Akasaki, Y., Ichimura, K. & Tanuma, S. I., 15 9月 2016, In: Tokyo Jikeikai Medical Journal. 131, 5, p. 141-147 7 p.

研究成果: Article › 査読

In vitro inhibition of Toxoplasma gondii by the anti-malarial candidate, 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol

Xin, C. F., Kim, H. S., Sato, A., Lee, H. J., Lee, Y. W., Pyo, K. H. & Shin, E. H., 1 10月 2016, In: Parasitology International. 65, 5, p. 494-499 6 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

MicroRNA-351 regulates two-types of cell death, necrosis and apoptosis, induced by 5-fluoro-2'-deoxyuridine

Sato, A., Omi, T., Yamamoto, A., Satake, A., Hiramoto, A., Masutani, M., Tanuma, S. I., Wataya, Y. & Kim, H. S., 4月 2016, In: PloS one. 11, 4, e0153130.

研究成果: Article › 査読

Open Access

18 被引用数 (Scopus)

2015

A comprehensive analysis of radiosensitization targets; Functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation

Fujimori, H., Sato, A., Kikuhara, S., Wang, J., Hirai, T., Sasaki, Y., Murakami, Y., Okayasu, R. & Masutani, M., 15 12月 2015, In: Scientific reports. 5, 18231.

研究成果: Article › 査読

Open Access

9 被引用数 (Scopus)

Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells

Sakagami, H., Shimada, C., Kanda, Y., Amano, O., Sugimoto, M., Ota, S., Soga, T., Tomita, M., Sato, A., Tanuma, S. I., Takao, K. & Sugita, Y., 1 12月 2015, In: Toxicology Reports. 2, p. 1281-1290 10 p.

研究成果: Article › 査読

Open Access

37 被引用数 (Scopus)

Improvement of oral bioavailability of n-251, a novel antimalarial drug, by increasing lymphatic transport with long-chain fatty acid-based self-nanoemulsifying drug delivery system

Imada, C., Takahashi, T., Kuramoto, M., Masuda, K., Ogawara, K. I., Sato, A., Wataya, Y., Kim, H. S. & Higaki, K., 1 8月 2015, In: Pharmaceutical Research. 32, 8, p. 2595-2608 14 p.

研究成果: Article › 査読

20 被引用数 (Scopus)

PARP and carcinogenesis

Wang, J., Sato, A., Fujimori, H., Miki, Y. & Masutani, M., 2015, In: Cancer Drug Discovery and Development. 83, p. 99-124 26 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells

Sato, A., Itoh, T., Imamichi, S., Kikuhara, S., Fujimori, H., Hirai, T., Saito, S., Sakurai, Y., Tanaka, H., Nakamura, H., Suzuki, M., Murakami, Y., Baiseitov, D., Berikkhanova, K., Zhumadilov, Z., Imahori, Y., Itami, J., Ono, K., Masunaga, S. & Masutani, M., 1 12月 2015, In: Applied Radiation and Isotopes. 106, p. 213-219 7 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Stage specific activity of synthetic antimalarial endoperoxides, N-89 and N-251, against Plasmodium falciparum

Morita, M., Koyama, T., Sanai, H., Sato, A., Hiramoto, A., Masuyama, A., Nojima, M., Wataya, Y. & Kim, H. S., 1 2月 2015, In: Parasitology International. 64, 1, p. 113-117 5 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

2014

Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5-fluoro-2′-deoxyuridine

Sato, A., Nakama, K., Watanabe, H., Satake, A., Yamamoto, A., Omi, T., Hiramoto, A., Masutani, M., Wataya, Y. & Kim, H. S., 4月 2014, In: FEBS Journal. 281, 7, p. 1892-1900 9 p.

研究成果: Article › 査読

Open Access

21 被引用数 (Scopus)

2013

New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication

Ueda, Y., Takeda, M., Mori, K., Dansako, H., Wakita, T., Kim, H. S., Sato, A., Wataya, Y., Ikeda, M. & Kato, N., 30 8月 2013, In: PloS one. 8, 8, e72519.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

2012

Andirolides H-P from the flower of andiroba (Carapa guianensis, Meliaceae)

Tanaka, Y., Sakamoto, A., Inoue, T., Yamada, T., Kikuchi, T., Kajimoto, T., Muraoka, O., Sato, A., Wataya, Y., Kim, H. S. & Tanaka, R., 6 5月 2012, In: Tetrahedron. 68, 18, p. 3669-3677 9 p.

研究成果: Article › 査読

32 被引用数 (Scopus)

Plasmodium falciparum endoplasmic reticulum-resident calcium binding protein is a possible target of synthetic antimalarial endoperoxides, n-89 and N-251

Morita, M., Sanai, H., Hiramoto, A., Sato, A., Hiraoka, O., Sakura, T., Kaneko, O., Masuyama, A., Nojima, M., Wataya, Y. & Kim, H. S., 7 12月 2012, In: Journal of Proteome Research. 11, 12, p. 5704-5711 8 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

2011

Antimalarial activity of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) and its carboxylic acid derivatives

Sato, A., Kawai, S., Hiramoto, A., Morita, M., Tanigawa, N., Nakase, Y., Komichi, Y., Matsumoto, M., Hiraoka, O., Hiramoto, K., Tokuhara, H., Masuyama, A., Nojima, M., Higaki, K., Hayatsu, H., Wataya, Y. & Kim, H. S., 12月 2011, In: Parasitology International. 60, 4, p. 488-492 5 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol

Sato, A., Hiramoto, A., Morita, M., Matsumoto, M., Komich, Y., Nakase, Y., Tanigawa, N., Hiraoka, O., Hiramoto, K., Hayatsu, H., Higaki, K., Kawai, S., Masuyama, A., Nojima, M., Wataya, Y. & Kim, H. S., 9月 2011, In: Parasitology International. 60, 3, p. 270-273 4 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

Schistosomicidal and antifecundity effects of oral treatment of synthetic endoperoxide N-89

Taniguchi, T., Kumagai, T., Shimogawara, R., Ichinose, S., Hiramoto, A., Sato, A., Morita, M., Nojima, M., Kim, H. S., Wataya, Y. & Ohta, N., 9月 2011, In: Parasitology International. 60, 3, p. 231-236 6 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

2010

Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line

Sato, A., Naito, T., Hiramoto, A., Goda, K., Omi, T., Kitade, Y., Sasaki, T., Matsuda, A., Fukushima, M., Wataya, Y. & Kim, H. S., 11月 2010, In: FEBS Journal. 277, 21, p. 4464-4473 10 p.

研究成果: Article › 査読

Open Access

24 被引用数 (Scopus)

Protein expression profiles of necrosis and apoptosis induced by 5-fluoro-2′-deoxyuridine in mouse cancer cells

Sato, A., Satake, A., Hiramoto, A., Wataya, Y. & Kim, H. S., 7 5月 2010, In: Journal of Proteome Research. 9, 5, p. 2329-2338 10 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

2009

Association of nuclear-intermediate filament lamin B1 with necrotic- and apoptotic-morphologies in cell death induced by 5-fluoro-2'-deoxyuridine.

Sato, A., Satake, A., Hiramoto, A., Okamatsu, A., Nakama, K., Kim, H. S. & Wataya, Y., 2009, In: Nucleic acids symposium series (2004). 53, p. 293-294 2 p.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

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佐藤聡