Tripodal thiol-derivatives as a functional interface monolayer for immobilization of biomolecules

Toshiya Sakata; Sumio Maruyama; Hidenori Otsuka; Yuji Miyahara

doi:10.1109/MMB.2005.1548430

Tripodal thiol-derivatives as a functional interface monolayer for immobilization of biomolecules

Toshiya Sakata, Sumio Maruyama, Hidenori Otsuka, Yuji Miyahara

Department of Applied Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

We designed interface molecules for immobilization of biomolecules on solid substrate and applied it to genetic field effect transistors. We have been investigating a new approach to realize a potentiometric detection for DNA chips. The concept of a genetic field effect transistor has been proposed for improving precision, standardization and miniaturization of a DNA chip system. We have designed and synthesized tripodal thiol-derivatives for stable immobilization of oligonucleotide probes on a gold surface. The genetic FET platform combined with the new interface molecule is suitable for a simple, accurate and inexpensive system for SNP typing In clinical diagnostics. α 2005 IEEE.

Original language	English
Title of host publication	2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Pages	215-218
Number of pages	4
DOIs	https://doi.org/10.1109/MMB.2005.1548430
Publication status	Published - 2005
Event	2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States Duration: 12 May 2005 → 15 May 2005

Publication series

Name	2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Volume	2005

Conference

Conference	2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Country/Territory	United States
City	Oahu, HI
Period	12/05/05 → 15/05/05

Keywords

DNA chip
Immobilization
Interface molecule

Access to Document

10.1109/MMB.2005.1548430

Cite this

Sakata, T., Maruyama, S., Otsuka, H., & Miyahara, Y. (2005). Tripodal thiol-derivatives as a functional interface monolayer for immobilization of biomolecules. In 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology (pp. 215-218). Article 1548430 (2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology; Vol. 2005). https://doi.org/10.1109/MMB.2005.1548430

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title = "Tripodal thiol-derivatives as a functional interface monolayer for immobilization of biomolecules",

abstract = "We designed interface molecules for immobilization of biomolecules on solid substrate and applied it to genetic field effect transistors. We have been investigating a new approach to realize a potentiometric detection for DNA chips. The concept of a genetic field effect transistor has been proposed for improving precision, standardization and miniaturization of a DNA chip system. We have designed and synthesized tripodal thiol-derivatives for stable immobilization of oligonucleotide probes on a gold surface. The genetic FET platform combined with the new interface molecule is suitable for a simple, accurate and inexpensive system for SNP typing In clinical diagnostics. α 2005 IEEE.",

keywords = "DNA chip, Immobilization, Interface molecule",

author = "Toshiya Sakata and Sumio Maruyama and Hidenori Otsuka and Yuji Miyahara",

year = "2005",

doi = "10.1109/MMB.2005.1548430",

language = "English",

isbn = "0780387112",

series = "2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology",

pages = "215--218",

booktitle = "2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology",

note = "2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology ; Conference date: 12-05-2005 Through 15-05-2005",

}

Sakata, T, Maruyama, S, Otsuka, H & Miyahara, Y 2005, Tripodal thiol-derivatives as a functional interface monolayer for immobilization of biomolecules. in 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology., 1548430, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, vol. 2005, pp. 215-218, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, Oahu, HI, United States, 12/05/05. https://doi.org/10.1109/MMB.2005.1548430

Tripodal thiol-derivatives as a functional interface monolayer for immobilization of biomolecules. / Sakata, Toshiya; Maruyama, Sumio; Otsuka, Hidenori et al.
2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. 2005. p. 215-218 1548430 (2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology; Vol. 2005).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - We designed interface molecules for immobilization of biomolecules on solid substrate and applied it to genetic field effect transistors. We have been investigating a new approach to realize a potentiometric detection for DNA chips. The concept of a genetic field effect transistor has been proposed for improving precision, standardization and miniaturization of a DNA chip system. We have designed and synthesized tripodal thiol-derivatives for stable immobilization of oligonucleotide probes on a gold surface. The genetic FET platform combined with the new interface molecule is suitable for a simple, accurate and inexpensive system for SNP typing In clinical diagnostics. α 2005 IEEE.

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Sakata T, Maruyama S, Otsuka H, Miyahara Y. Tripodal thiol-derivatives as a functional interface monolayer for immobilization of biomolecules. In 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. 2005. p. 215-218. 1548430. (2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology). doi: 10.1109/MMB.2005.1548430

Tripodal thiol-derivatives as a functional interface monolayer for immobilization of biomolecules

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Keywords

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