Towards Virtual Bioequivalence Studies for Oral Dosage Forms Containing Poorly Water-Soluble Drugs: A Physiologically Based Biopharmaceutics Modeling (PBBM) Approach

Keyphrases

• Physiologically-based Pharmacokinetic Model 100%
• Oral Dosage Forms 100%
• Poorly Water-soluble Drugs 100%
• Modeling Approach 100%
• Bioequivalence 100%
• Bioequivalence Study 100%
• Virtual Bioequivalence 100%
• Physiological Parameters 50%
• Dosage Forms 50%
• Gastrointestinal 50%
• Confidence Interval 25%
• Virtual Humans 25%
• In Vitro Study 25%
• Human Subjects 25%
• Stomach 25%
• In Silico 25%
• Model Simulation 25%
• Geometric Mean 25%
• Volume of Fluid 25%
• Gastric Fluid 25%
• Tablet Formulation 25%
• Ratio of Means 25%
• Inter-individual Variability 25%
• Precise Prediction 25%
• In Vitro Dissolution 25%
• Gastric Emptying 25%
• Dissolution Performance 25%
• Physiologically Based 25%
• Biorelevant Dissolution Testing 25%
• Enzalutamide 25%
• Inter-subject 25%
• Virtual Studies 25%
• Aripiprazole 25%
• Biopharmaceutics 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Pharmaceutics 100%
• Dosage Forms 100%
• Bioequivalence 100%
• Tablet 20%
• Enzalutamide 20%
• Aripiprazole 20%
• Homo sapiens 20%