Thermoresponsive nanobio surfaces for regenerative medicine prepared by iniferter polymerization

Kenjiro Hira; Yukiko Tsuda; Akihiko Kikuchi; Kiyotaka Sakai; Teruo Okano

Thermoresponsive nanobio surfaces for regenerative medicine prepared by iniferter polymerization

Kenjiro Hira, Yukiko Tsuda, Akihiko Kikuchi, Kiyotaka Sakai, Teruo Okano

Department of Materials Science and Technology

Research output: Contribution to conference › Paper › peer-review

Abstract

In this study, light induced iniferter polymerization was utilized to prepare thermoresponsive nanobio surfaces for possible recovery of tissue mimicking cell sheet. Poly(N-isopropylacrylamide) (PIPAAm) was grafted onto glass surfaces using iniferter polymerization method with varying monomer concentrations. Several surface analyses including XPS analyses, static contact angle measurements and AFM revealed that prepared surfaces were successfully modified with PIPAAm. PIPAAm-grafted surfaces showed cell adhesion/detachment control by changes in culture temperature. Confluently cultured cells were able to harvest as a tissue-like cell sheet from the prepared surfaces.

Original language	English
Pages	5223-5224
Number of pages	2
Publication status	Published - 2005
Event	54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: 20 Sept 2005 → 22 Sept 2005

Conference

Conference	54th SPSJ Symposium on Macromolecules
Country/Territory	Japan
City	Yamagata
Period	20/09/05 → 22/09/05

Keywords

Endotherial cells
Iniferter polymerization
Poly(N-isopropylacryamide)
Thermoresponsive surfaces

Cite this

@conference{9ad6a96d677646439599636741554993,

title = "Thermoresponsive nanobio surfaces for regenerative medicine prepared by iniferter polymerization",

abstract = "In this study, light induced iniferter polymerization was utilized to prepare thermoresponsive nanobio surfaces for possible recovery of tissue mimicking cell sheet. Poly(N-isopropylacrylamide) (PIPAAm) was grafted onto glass surfaces using iniferter polymerization method with varying monomer concentrations. Several surface analyses including XPS analyses, static contact angle measurements and AFM revealed that prepared surfaces were successfully modified with PIPAAm. PIPAAm-grafted surfaces showed cell adhesion/detachment control by changes in culture temperature. Confluently cultured cells were able to harvest as a tissue-like cell sheet from the prepared surfaces.",

keywords = "Endotherial cells, Iniferter polymerization, Poly(N-isopropylacryamide), Thermoresponsive surfaces",

author = "Kenjiro Hira and Yukiko Tsuda and Akihiko Kikuchi and Kiyotaka Sakai and Teruo Okano",

year = "2005",

language = "English",

pages = "5223--5224",

note = "54th SPSJ Symposium on Macromolecules ; Conference date: 20-09-2005 Through 22-09-2005",

}

TY - CONF

T1 - Thermoresponsive nanobio surfaces for regenerative medicine prepared by iniferter polymerization

AU - Hira, Kenjiro

AU - Tsuda, Yukiko

AU - Kikuchi, Akihiko

AU - Sakai, Kiyotaka

AU - Okano, Teruo

PY - 2005

Y1 - 2005

N2 - In this study, light induced iniferter polymerization was utilized to prepare thermoresponsive nanobio surfaces for possible recovery of tissue mimicking cell sheet. Poly(N-isopropylacrylamide) (PIPAAm) was grafted onto glass surfaces using iniferter polymerization method with varying monomer concentrations. Several surface analyses including XPS analyses, static contact angle measurements and AFM revealed that prepared surfaces were successfully modified with PIPAAm. PIPAAm-grafted surfaces showed cell adhesion/detachment control by changes in culture temperature. Confluently cultured cells were able to harvest as a tissue-like cell sheet from the prepared surfaces.

AB - In this study, light induced iniferter polymerization was utilized to prepare thermoresponsive nanobio surfaces for possible recovery of tissue mimicking cell sheet. Poly(N-isopropylacrylamide) (PIPAAm) was grafted onto glass surfaces using iniferter polymerization method with varying monomer concentrations. Several surface analyses including XPS analyses, static contact angle measurements and AFM revealed that prepared surfaces were successfully modified with PIPAAm. PIPAAm-grafted surfaces showed cell adhesion/detachment control by changes in culture temperature. Confluently cultured cells were able to harvest as a tissue-like cell sheet from the prepared surfaces.

KW - Endotherial cells

KW - Iniferter polymerization

KW - Poly(N-isopropylacryamide)

KW - Thermoresponsive surfaces

UR - http://www.scopus.com/inward/record.url?scp=33645573582&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645573582

SP - 5223

EP - 5224

T2 - 54th SPSJ Symposium on Macromolecules

Y2 - 20 September 2005 through 22 September 2005

ER -

Thermoresponsive nanobio surfaces for regenerative medicine prepared by iniferter polymerization

Abstract

Conference

Keywords

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