The function of oxybuprocaine: A: Parachute effect that sustains the supersaturated state of anhydrous piroxicam crystals

Momoko Fujita, Satoru Goto, Hitoshi Chatani, Yuta Otsuka, Yohsuke Shimada, Hiroshi Terada, Katsuyuki Inoo

Research output: Contribution to journalArticle

Abstract

Polymers have been recognized to have the function of sustaining the supersaturated state of drugs. This function has been widely studied because it will improve the absorption of poorly water-soluble drugs. However, clarifying the mechanism of this sustaining pharmaceutical effect (parachute effect) on the supersaturated state as a result of polymers is remains a task. We have found that oxybuprocaine, which is a small molecule, has a parachute effect on the supersaturated state (due to an anhydrate-to-hydrate transformation) of piroxicam-anhydrate in the aqueous phase. We consider that oxybuprocaine controls the environment of the solution and the network of polymers is unnecessary. Therefore, oxybuprocaine not only becomes a clue for elucidating the essential mechanism of the parachute effect of polymers but also enables us to rationally propose a new type of solubilizer.

Original languageEnglish
Pages (from-to)1572-1579
Number of pages8
JournalRSC Advances
Volume10
Issue number3
DOIs
Publication statusPublished - 1 Jan 2020

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