The crystal structure of a 2′,4′-BNANC[N-Me]-modified antisense gapmer in complex with the target RNA

Jiro Kondo, Yusuke Nomura, Yukiko Kitahara, Satoshi Obika, Hidetaka Torigoe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It has been confirmed by our previous studies that a 2′,4′-BNANC[N-Me]-modified antisense gapmer displays high affinity and selectivity to the target RNA strand, promising mRNA inhibitory activity and excellent nuclease resistance. Herein, we have obtained a crystal structure that provides insights into these excellent antisense properties.

Original languageEnglish
Pages (from-to)2354-2357
Number of pages4
JournalChemical Communications
Volume52
Issue number11
DOIs
Publication statusPublished - 7 Feb 2016

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