Temperature-sensitive poly(N-isopropylacrylamide)-grafted surfaces modulate blood platelet interactions'

Katsumi Uchida, Kiyotaka Sakai, Oh Hyeong Kwon, Etsuko Ito, Takao Aoyagi, Akihiko Kikuchi, Masayuki Yamato, Teruo Okano

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Interactions between a temperature-responsive poly(N-isopropylacrylamide)-grafted surface and blood platelets have been analyzed with computerized image analysis. Platelet behavior on this surface is dramatically dependent upon temperature in contrast to that on poly(ethylene glycol) (PEG)-grafted surfaces or polystyrene. The poly(N-isopropylacrylamide)-grafted surface interacts with platelets similarly as the poly(ethylene glycol)-rafted surface at 18°C. At 37°C, platelets readily adhere onto the poly(N-isopropylacrylamide)-grafted surface similarly as to that of polystyrene.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalMacromolecular Rapid Communications
Issue number4
Publication statusPublished - 24 Feb 2000

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