Synthesis of 12,12a-dihydro-7,12a-diazacyclohepta[cd]-benz[g]azulen-12-one (cyclohepta[mn]pyrrolo[2,1-c][1,4]-benzodiazepin-12-one) and evaluation of cytotoxic activity against HeLa S3 cells

Eiko Yoshioka, Hiroyuki Fujii, Toshihiro Murafuji, Reiko Ikeda, Takeo Konakahara, Takahiro Gunji, Noritaka Abe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

12,12a-dihydro-7,12a-diazacyclohepta[cd]benz[g]azulen-12-one (cyclohepta[mn]pyrrolo[2,1-c][1,4]benzodiazepin-12-one) derivative (7) was synthesized by the intramolecular cyclization of methyl 2-(3-phenyl-1-azaazulen- 8-yl)aminobenzoate. Compound (7) showed extremely strong cytotoxic activity against HeLa S3 cells (IC50=0.543±0.063 μM).

Original languageEnglish
Pages (from-to)1409-1415
Number of pages7
JournalHeterocycles
Volume83
Issue number6
DOIs
Publication statusPublished - 26 May 2011

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