Superoxide anion radical sensor using GC electrode modified with heparin/PEDOT and polymerized iron porphyrin

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Abstract

Blood coagulation on the electrode surface is a serious problem for a superoxide anion radical (O2-·) sensor because it causes deterioration of the current signal especially in vivo. In order to solve this problem, we have developed iron porphyrin-based O2 -· sensors immobilizing heparin, which is an anti-thrombotic compound, on the surface. In the present study, we immobilized heparin with a polyethylenedioxythiophene (PEDOT) matrix on poly[iron tetrakis(3-thienyl) porphyrin]-modified glassy carbon (GC) electrode, and the stability of the modified sensor to blood coagulation was investigated. The PEDOT matrix was found to be more effective for stable electrochemical detection of O 2-· after immersion in a fibrinogen/thrombin solution for two weeks, while serious electrode fouling due to blood clot formation was occurred at a sensor using a polypyrrole matrix after immersion in the solution for one week.

Original languageEnglish
Title of host publicationChemical Sensors 10 -and- MEMS/NEMS 10
Pages369-376
Number of pages8
Edition12
DOIs
Publication statusPublished - 1 Dec 2012
EventSymposia on Chemical Sensors 10 - Chemical and Biological Sensors and Analytical Systems and Microfabricated and Nanofabricated Systems for MEMS/NEMS 10 - 222nd ECS Meeting/PRiME 2012 - Honolulu, HI, United States
Duration: 7 Oct 201212 Oct 2012

Publication series

NameECS Transactions
Number12
Volume50
ISSN (Print)1938-5862
ISSN (Electronic)1938-6737

Conference

ConferenceSymposia on Chemical Sensors 10 - Chemical and Biological Sensors and Analytical Systems and Microfabricated and Nanofabricated Systems for MEMS/NEMS 10 - 222nd ECS Meeting/PRiME 2012
CountryUnited States
CityHonolulu, HI
Period7/10/1212/10/12

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Matsuoka, R., Kondo, T., & Yuasa, M. (2012). Superoxide anion radical sensor using GC electrode modified with heparin/PEDOT and polymerized iron porphyrin. In Chemical Sensors 10 -and- MEMS/NEMS 10 (12 ed., pp. 369-376). (ECS Transactions; Vol. 50, No. 12). https://doi.org/10.1149/05012.0369ecst