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Structural insights into the active site of poly(ADP-ribose) glycohydrolase using docking modes of 6-hydroxy-3H-xanthen-3-one derivative inhibitors
Yuto Shibui
, Takahiro Oyama
, Miwa Okazawa
, Atsushi Yoshimori
, Hideaki Abe
,
Fumiaki Uchiumi
, Sei ichi Tanuma
Department of Medicinal and Life Sciences
Research Institute for Science and Technology
Research output
:
Contribution to journal
›
Article
›
peer-review
2
Citations (Scopus)
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Dive into the research topics of 'Structural insights into the active site of poly(ADP-ribose) glycohydrolase using docking modes of 6-hydroxy-3H-xanthen-3-one derivative inhibitors'. Together they form a unique fingerprint.
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Keyphrases
Active Sites
100%
Structural Insights
100%
Poly(ADP-ribose) Glycohydrolase
100%
Docking Mode
100%
Xanthene
37%
Inhibitory Activity
25%
Binding Mode
25%
Rose Bengal
25%
Binding Energy
12%
Potent Inhibitor
12%
DNA Replication
12%
DNA Repair
12%
Binding Affinity
12%
Stable Configuration
12%
Poly(ADP-ribose)
12%
Iodine Atom
12%
DNA Transactions
12%
In Silico Docking
12%
DNA Recombination
12%
Chlorine Atom
12%
Halogen Group
12%
Structural Plasticity
12%
Active Pocket
12%
Biochemistry, Genetics and Molecular Biology
Active Site
100%
Glycoside Hydrolase
100%
Adenosine Diphosphate Ribose
100%
Rose Bengal
22%
Binding Affinity
11%
Transcription
11%
DNA Synthesis
11%
Tincture of Iodine
11%
DNA Repair
11%
DNA Recombination
11%
Pharmacology, Toxicology and Pharmaceutical Science
Glycosidase
100%
Poly(adenosine Diphosphate Ribose)
100%
Xanthene
33%
Rose Bengal
22%