Silica-based nonwoven fiber fabricated by electrospinning to promote fibroblast functions

Shohei Ishikawa; Kazutoshi Iijima; Kohei Sasaki; Masaaki Kawabe; Shigehito Osawa; Hidenori Otsuka

doi:10.1246/BCSJ.20190318

Silica-based nonwoven fiber fabricated by electrospinning to promote fibroblast functions

Shohei Ishikawa, Kazutoshi Iijima, Kohei Sasaki, Masaaki Kawabe, Shigehito Osawa, Hidenori Otsuka

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Cellular engraftment onto an engineered scaffold is of significant importance for successful implantation. Herein, we propose the use of three-dimensional (3D) silica nonwoven fabrics (SNFs, Cellbed®) synthesized using the electrospinning method, which creates an excellent environment for greater cultured cell growth and subsequent tissue formation due to preserving the extracellular matrix (ECM)-mimetic inherent structure of the scaffold. Regarding the fibroblast culture on the scaffold, cellular function, in terms of collagen type I synthesis, was more enhanced than that of the conventional plane culture due to the efficient permeability and satisfactory physiological morphologies of 3D SNFs.

Original language	English
Pages (from-to)	477-481
Number of pages	5
Journal	Bulletin of the Chemical Society of Japan
Volume	93
Issue number	4
DOIs	https://doi.org/10.1246/BCSJ.20190318
Publication status	Published - Apr 2020

Keywords

Electrospinning
Fibroblasts
Silica nonwoven fabrics

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title = "Silica-based nonwoven fiber fabricated by electrospinning to promote fibroblast functions",

abstract = "Cellular engraftment onto an engineered scaffold is of significant importance for successful implantation. Herein, we propose the use of three-dimensional (3D) silica nonwoven fabrics (SNFs, Cellbed{\textregistered}) synthesized using the electrospinning method, which creates an excellent environment for greater cultured cell growth and subsequent tissue formation due to preserving the extracellular matrix (ECM)-mimetic inherent structure of the scaffold. Regarding the fibroblast culture on the scaffold, cellular function, in terms of collagen type I synthesis, was more enhanced than that of the conventional plane culture due to the efficient permeability and satisfactory physiological morphologies of 3D SNFs.",

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T1 - Silica-based nonwoven fiber fabricated by electrospinning to promote fibroblast functions

AU - Ishikawa, Shohei

AU - Iijima, Kazutoshi

AU - Sasaki, Kohei

AU - Kawabe, Masaaki

AU - Osawa, Shigehito

AU - Otsuka, Hidenori

PY - 2020/4

Y1 - 2020/4

N2 - Cellular engraftment onto an engineered scaffold is of significant importance for successful implantation. Herein, we propose the use of three-dimensional (3D) silica nonwoven fabrics (SNFs, Cellbed®) synthesized using the electrospinning method, which creates an excellent environment for greater cultured cell growth and subsequent tissue formation due to preserving the extracellular matrix (ECM)-mimetic inherent structure of the scaffold. Regarding the fibroblast culture on the scaffold, cellular function, in terms of collagen type I synthesis, was more enhanced than that of the conventional plane culture due to the efficient permeability and satisfactory physiological morphologies of 3D SNFs.

AB - Cellular engraftment onto an engineered scaffold is of significant importance for successful implantation. Herein, we propose the use of three-dimensional (3D) silica nonwoven fabrics (SNFs, Cellbed®) synthesized using the electrospinning method, which creates an excellent environment for greater cultured cell growth and subsequent tissue formation due to preserving the extracellular matrix (ECM)-mimetic inherent structure of the scaffold. Regarding the fibroblast culture on the scaffold, cellular function, in terms of collagen type I synthesis, was more enhanced than that of the conventional plane culture due to the efficient permeability and satisfactory physiological morphologies of 3D SNFs.

KW - Electrospinning

KW - Fibroblasts

KW - Silica nonwoven fabrics

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JO - Bulletin of the Chemical Society of Japan

JF - Bulletin of the Chemical Society of Japan

IS - 4

ER -

Silica-based nonwoven fiber fabricated by electrospinning to promote fibroblast functions

Abstract

Keywords

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