TY - JOUR
T1 - Ru(II)-Catalyzed Regiospecific C-H/O-H Oxidative Annulation to Access Isochromeno[8,1-ab]phenazines
T2 - Far-Red Fluorescence and Live Cancer Cell Imaging
AU - Mayakrishnan, Sivakalai
AU - Arun, Yuvaraj
AU - Balachandran, Chandrasekar
AU - Awale, Suresh
AU - Maheswari, Narayanan Uma
AU - Perumal, Paramasivan Thirumalai
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/6/30
Y1 - 2017/6/30
N2 - A facile ruthenium(II)-catalyzed regiospecific C-H/O-H oxidative annulation methodology was developed to construct isochromeno[8,1-ab]phenazines. This methodology delivers various advantages, such as scope for diverse substrates, tolerance to a range of functional groups, stability under air, and yields regioselective products. This methodology was successfully applied to synthesize far red (FR) fluorescent probes for live cancer cell imaging. The synthesized compounds displayed notable fluorescence properties in solution and thin-film. Their application in live cancer cell imaging was investigated using various cancer cell lines. The synthesized compound showed prominent FR fluorescence, with high quantum yield, and exhibited better cell-imaging properties, with excellent biocompatibility.
AB - A facile ruthenium(II)-catalyzed regiospecific C-H/O-H oxidative annulation methodology was developed to construct isochromeno[8,1-ab]phenazines. This methodology delivers various advantages, such as scope for diverse substrates, tolerance to a range of functional groups, stability under air, and yields regioselective products. This methodology was successfully applied to synthesize far red (FR) fluorescent probes for live cancer cell imaging. The synthesized compounds displayed notable fluorescence properties in solution and thin-film. Their application in live cancer cell imaging was investigated using various cancer cell lines. The synthesized compound showed prominent FR fluorescence, with high quantum yield, and exhibited better cell-imaging properties, with excellent biocompatibility.
UR - http://www.scopus.com/inward/record.url?scp=85028968913&partnerID=8YFLogxK
U2 - 10.1021/acsomega.7b00335
DO - 10.1021/acsomega.7b00335
M3 - Article
AN - SCOPUS:85028968913
SN - 2470-1343
VL - 2
SP - 2694
EP - 2705
JO - ACS Omega
JF - ACS Omega
IS - 6
ER -