TY - JOUR
T1 - Rh(iii)-Catalysed synthesis of cinnolinium and fluoranthenium salts using C-H activation/annulation reactions
T2 - organelle specific mitochondrial staining applications
AU - Mayakrishnan, Sivakalai
AU - Tamizmani, Masilamani
AU - Balachandran, Chandrasekar
AU - Aoki, Shin
AU - Maheswari, Narayanan Uma
N1 - Funding Information:
Sivakalai Mayakrishnan acknowledges the CSIR, India, for providing a Senior Research Fellowship (Grant No. 31/6(422)/ 2017-EMR-I). Narayanan Uma Maheswari acknowledges the Director of CSIR-CLRI for providing a congenial environment.
Funding Information:
Sivakalai Mayakrishnan acknowledges the CSIR, India, for providing a Senior Research Fellowship (Grant No. 31/6(422)/2017-EMR-I). Narayanan Uma Maheswari acknowledges the Director of CSIR-CLRI for providing a congenial environment.
Publisher Copyright:
© The Royal Society of Chemistry 2021.
PY - 2021/6/28
Y1 - 2021/6/28
N2 - The construction of a novel class of indazolo[2,1-a]cinnolin-7-ium and diazabenzofluoranthenium salts was developed by using Rh(iii)-catalyzed C-H activation/annulation reactions with 2-phenyl-2H-indazole, and internal alkynes, which resulted in structurally important polycyclic heteroaromatic compounds (PHAs). This reaction uses mild reaction conditions and has a high efficiency, low catalyst loading, and wide substrate scope. The overall catalytic process involves C-H activation followed by C-C/C-N bond formation. Furthermore, the synthesised cinnolinium/fluoranthenium salts exhibit potential fluorescence properties and5iwas targeted in particular for specific mitochondrial staining in order to investigate cancer cell lines.
AB - The construction of a novel class of indazolo[2,1-a]cinnolin-7-ium and diazabenzofluoranthenium salts was developed by using Rh(iii)-catalyzed C-H activation/annulation reactions with 2-phenyl-2H-indazole, and internal alkynes, which resulted in structurally important polycyclic heteroaromatic compounds (PHAs). This reaction uses mild reaction conditions and has a high efficiency, low catalyst loading, and wide substrate scope. The overall catalytic process involves C-H activation followed by C-C/C-N bond formation. Furthermore, the synthesised cinnolinium/fluoranthenium salts exhibit potential fluorescence properties and5iwas targeted in particular for specific mitochondrial staining in order to investigate cancer cell lines.
UR - http://www.scopus.com/inward/record.url?scp=85108570506&partnerID=8YFLogxK
U2 - 10.1039/d1ob00376c
DO - 10.1039/d1ob00376c
M3 - Article
C2 - 34047328
AN - SCOPUS:85108570506
SN - 1477-0520
VL - 19
SP - 5413
EP - 5425
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 24
ER -