Recent topics in total syntheses of natural dimeric naphthoquinone derivatives

Shogo Kamo, Kouji Kuramochi, Kazunori Tsubaki

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

This digest overviews successful synthetic approaches to natural dimeric 1,4-naphthoquinones. Several natural dimeric 1,4-naphthoquinone derivatives have been isolated from natural sources including plants, bacteria, and fungi. They have diverse structures and attractive biological activities. However, it is difficult to construct the dimeric scaffolds efficiently and selectively, because 1,4-naphthoquinones and their derivatives are highly reactive. Efficient and attractive synthetic methodologies to construct unique dimeric 1,4-naphthoquinone skeletons are reviewed.

Original languageEnglish
Pages (from-to)224-230
Number of pages7
JournalTetrahedron Letters
Volume59
Issue number3
DOIs
Publication statusPublished - 17 Jan 2018

Keywords

  • 1,4-Naphthoquinones
  • Dimerization
  • Natural product
  • Total synthesis

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