Recent Advances in Magnesium Carbenoid Chemistry

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Magnesium carbenoids are a class of organomagnesium species possessing a halo group at the α-position. The reactions of magnesium carbenoids can be classified into the following three categories: nucleophilic reactions resembling Grignard reagents, electrophilic reactions resembling organic halides, and rearrangements resembling carbenes. This short review summarizes recent studies on magnesium carbenoids reported between 2010 and 2016, and milestone studies reported before 2010 according to the classification of the reactions into the aforementioned three categories. 1 Introduction 2 Structures of Magnesium Carbenoids 3 Reactions of Magnesium Carbenoids as Nucleophiles 3.1 Nucleophilic Reactions of Magnesium Carbenoids 3.2 Nucleophilic Reactions of Magnesium Alkylidene Carbenoids 3.3 Nucleophilic Reactions of Cyclopropylmagnesium Carbenoids 4 Electrophilic Reactions of Magnesium Carbenoids 4.1 Reactions with Nucleophiles Followed by Electrophiles 4.2 Reactions with Nucleophiles Possessing Electrophilic Functional Groups 4.3 Nucleophilic Substitution Followed by β-Elimination 5 Rearrangements of Magnesium Carbenoids 5.1 1,2-Shifts of Magnesium Carbenoids 5.2 1,3-C-H Insertions of Magnesium Carbenoids 5.3 1,5-C-H Insertions of Magnesium Carbenoids 5.4 [2+1] Cycloaddition of a Magnesium Carbenoid 6 Conclusion and Outlook.

Original languageEnglish
Pages (from-to)5105-5119
Number of pages15
JournalSynthesis (Germany)
Issue number23
Publication statusPublished - 1 Dec 2017



  • carbenes
  • carbenoids
  • Grignard reaction
  • magnesium
  • organometallic reagents
  • rearrangement
  • sulfoxides

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