Protective effects of cyclodextrins on edaravone degradation induced by atmospheric oxygen or additive oxidant

Ryosuke Hiroshige, Satoru Goto, Risa Ichii, Shota Shimizu, Ayako Wada-Hirai, Ying Peng Li, Yohsuke Shimada, Yuta Otsuka, Kosho Makino, Hideyo Takahashi

Research output: Contribution to journalArticlepeer-review


Abstract: Antioxidants scavenge free radicals and may help prevent disease. However, due to poor stability, continuous intake is required. This study investigates the ability of cyclodextrin inclusion to improve the stability of the novel antioxidant edaravone. Kinetic models of cyclodextrin protection against edaravone oxidative decomposition were assessed and the data obtained was analyzed using Hanes–Woolf plots and Scatchard plots. In addition, complexation was analyzed using phase-solubility diagrams. The results show that cyclodextrin inclusion can control the oxidation rate of antioxidant molecules such as edaravone. This paper also demonstrates a substantial variation in the quantitative stability constant when calculated using different methods. This observation is relevant to determining complexation during the many and varied applications of cyclodextrins. The study establishes mechanisms to enhance the stability of antioxidants, which in turn may be useful to improve their bioavailability and may have translational implications in future. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)327-338
Number of pages12
JournalJournal of Inclusion Phenomena and Macrocyclic Chemistry
Issue number3-4
Publication statusPublished - Apr 2022


  • Antioxidant
  • Cyclodextrin
  • Edaravone
  • Scatchard plot


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