TY - JOUR
T1 - Preparing and Characterizing of Xyloglucan Films Containing Tea Extract for Oral Mucositis
AU - Hirose, Kaoru
AU - Nitto, Rieko
AU - Yokota, Shohtaro
AU - Kawano, Yayoi
AU - Yamatoya, Kazuhiko
AU - Tabuchi, Akira
AU - Suzuki, Yumeo
AU - Hanawa, Takehisa
N1 - Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society.
PY - 2025/1/14
Y1 - 2025/1/14
N2 - This study aimed to prepare films using Xyloglucan (Xylo) and tea extract (TE) to treat aphthous stomatitis without causing discomfort. Xylo, which gelates by adding polyphenol, was used as a gelation agent, and TE, which contains epigallocatechin-3-gallate (EGCG) with antioxidant properties, was used as an active pharmaceutical agent. Two kinds of films, hydrogel and xerogel films, were prepared by mixing various amounts of Xylo and TE. Their gelling behavior and physicochemical properties were evaluated. The sol-gel transition temperature increased with increased TE content, and the rupture strength of the films increased with increasing Xylo and TE concentrations. Rapid water absorption and high adhesiveness were observed during the reconstruction process from the xerogel to the hydrogel. The concentrations of Xylo and TE controlled the formulations’ physicochemical properties and the EGCG release rate. These results concluded that the xerogel prepared by using Xylo and TE could be applied as an oral mucosal adherent film formulation.
AB - This study aimed to prepare films using Xyloglucan (Xylo) and tea extract (TE) to treat aphthous stomatitis without causing discomfort. Xylo, which gelates by adding polyphenol, was used as a gelation agent, and TE, which contains epigallocatechin-3-gallate (EGCG) with antioxidant properties, was used as an active pharmaceutical agent. Two kinds of films, hydrogel and xerogel films, were prepared by mixing various amounts of Xylo and TE. Their gelling behavior and physicochemical properties were evaluated. The sol-gel transition temperature increased with increased TE content, and the rupture strength of the films increased with increasing Xylo and TE concentrations. Rapid water absorption and high adhesiveness were observed during the reconstruction process from the xerogel to the hydrogel. The concentrations of Xylo and TE controlled the formulations’ physicochemical properties and the EGCG release rate. These results concluded that the xerogel prepared by using Xylo and TE could be applied as an oral mucosal adherent film formulation.
UR - https://www.scopus.com/pages/publications/85213048326
U2 - 10.1021/acsomega.4c06410
DO - 10.1021/acsomega.4c06410
M3 - Article
AN - SCOPUS:85213048326
SN - 2470-1343
VL - 10
SP - 390
EP - 399
JO - ACS Omega
JF - ACS Omega
IS - 1
ER -