Preparation of Spherical Nucleic Acid Nanoparticles Containing a Self-immolative Poly(carbamate) Core

Shione Fukumoto, Mami Kawade, Kazunori Kimura, Yoshitsugu Akiyama, Akihiko Kikuchi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We prepared a novel spherical nucleic acid, containing a core structure of self-immolative poly(carbamate) (PC), with aminobenzyl alcohol as a repeating unit, by conjugating an end-activated PC derivative with an amine-terminated oligoDNA on a solid support for PC-oligoDNA. Dynamic light-scattering measurements revealed a hydrodynamic diameter of 107 nm with a narrow size distribution. A fluorescent monomer with aminobenzyl alcohol is available for PC-oligoDNA synthesis to enhance the fluorescence emission by a domino-like disassembly of PC in response to various external stimuli.

Original languageEnglish
Pages (from-to)781-784
Number of pages4
JournalAnalytical Sciences
Volume37
Issue number5
DOIs
Publication statusPublished - May 2021

Keywords

  • DNA conjugation
  • Spherical nucleic acids
  • poly(carbamate)
  • self-immolative polymer

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