Preparation of novel chromatography matrices having thermoresponisve polymer brush structure

Kenichi Nagase; Aya Mizutani; Jun Kobayashi; Akihiko Kikuchi; Yoshikatsu Akiyama; Hideko Kanazawa; Teruo Okano

Preparation of novel chromatography matrices having thermoresponisve polymer brush structure

Kenichi Nagase, Aya Mizutani, Jun Kobayashi, Akihiko Kikuchi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

Department of Materials Science and Technology

Research output: Contribution to conference › Paper › peer-review

Abstract

We prepared Chromatography matrices having thermoresponisve polymer brush structure by atom transfer radical polymerization (ATRP) of N- isopropylacrylamide (IPAAm) on silica beads. Retention times for steroids extended with increasing grafted PIPAAm amounts controlled by polymerizatuion times. Elution profiles of steroids on column packed with PIPAAm-grafted matrices prepared by ATRP depend largely on the column temperature. This indicates that matrices having thermoresponisve polymer brush layers would be useful for controlling strong hydrophobicity of HPLC stationary phases simply by changing column temperature.

Original language	English
Number of pages	1
Publication status	Published - 1 Dec 2005
Event	54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: 20 Sept 2005 → 22 Sept 2005

Conference

Conference	54th SPSJ Symposium on Macromolecules
Country/Territory	Japan
City	Yamagata
Period	20/09/05 → 22/09/05

Keywords

Green chemistry
Hydrophobic Chromatography
Living radical polymerization
Polymer brush
Thermoresponsive surfaces

Cite this

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title = "Preparation of novel chromatography matrices having thermoresponisve polymer brush structure",

abstract = "We prepared Chromatography matrices having thermoresponisve polymer brush structure by atom transfer radical polymerization (ATRP) of N- isopropylacrylamide (IPAAm) on silica beads. Retention times for steroids extended with increasing grafted PIPAAm amounts controlled by polymerizatuion times. Elution profiles of steroids on column packed with PIPAAm-grafted matrices prepared by ATRP depend largely on the column temperature. This indicates that matrices having thermoresponisve polymer brush layers would be useful for controlling strong hydrophobicity of HPLC stationary phases simply by changing column temperature.",

keywords = "Green chemistry, Hydrophobic Chromatography, Living radical polymerization, Polymer brush, Thermoresponsive surfaces",

author = "Kenichi Nagase and Aya Mizutani and Jun Kobayashi and Akihiko Kikuchi and Yoshikatsu Akiyama and Hideko Kanazawa and Teruo Okano",

year = "2005",

month = dec,

day = "1",

language = "English",

note = "54th SPSJ Symposium on Macromolecules ; Conference date: 20-09-2005 Through 22-09-2005",

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TY - CONF

T1 - Preparation of novel chromatography matrices having thermoresponisve polymer brush structure

AU - Nagase, Kenichi

AU - Mizutani, Aya

AU - Kobayashi, Jun

AU - Kikuchi, Akihiko

AU - Akiyama, Yoshikatsu

AU - Kanazawa, Hideko

AU - Okano, Teruo

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We prepared Chromatography matrices having thermoresponisve polymer brush structure by atom transfer radical polymerization (ATRP) of N- isopropylacrylamide (IPAAm) on silica beads. Retention times for steroids extended with increasing grafted PIPAAm amounts controlled by polymerizatuion times. Elution profiles of steroids on column packed with PIPAAm-grafted matrices prepared by ATRP depend largely on the column temperature. This indicates that matrices having thermoresponisve polymer brush layers would be useful for controlling strong hydrophobicity of HPLC stationary phases simply by changing column temperature.

AB - We prepared Chromatography matrices having thermoresponisve polymer brush structure by atom transfer radical polymerization (ATRP) of N- isopropylacrylamide (IPAAm) on silica beads. Retention times for steroids extended with increasing grafted PIPAAm amounts controlled by polymerizatuion times. Elution profiles of steroids on column packed with PIPAAm-grafted matrices prepared by ATRP depend largely on the column temperature. This indicates that matrices having thermoresponisve polymer brush layers would be useful for controlling strong hydrophobicity of HPLC stationary phases simply by changing column temperature.

KW - Green chemistry

KW - Hydrophobic Chromatography

KW - Living radical polymerization

KW - Polymer brush

KW - Thermoresponsive surfaces

UR - http://www.scopus.com/inward/record.url?scp=33645635695&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645635695

T2 - 54th SPSJ Symposium on Macromolecules

Y2 - 20 September 2005 through 22 September 2005

ER -

Preparation of novel chromatography matrices having thermoresponisve polymer brush structure

Abstract

Conference

Keywords

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