Preparation of functionally PEGylated gold nanoparticles with narrow distribution through autoreduction of auric cation by α-Biotinyl-PEG-block-[poly(2-(N,N-dimethylamino)ethyl methacrylate)]

Takehiko Ishii; Hidenori Otsuka; Kazunori Kataoka; Yukio Nagasaki

doi:10.1021/la035653i

Preparation of functionally PEGylated gold nanoparticles with narrow distribution through autoreduction of auric cation by α-Biotinyl-PEG-block-[poly(2-(N,N-dimethylamino)ethyl methacrylate)]

Takehiko Ishii, Hidenori Otsuka, Kazunori Kataoka, Yukio Nagasaki

Department of Applied Chemistry

Research output: Contribution to journal › Letter › peer-review

187 Citations (Scopus)

Abstract

PEGylated gold nanoparticles with biotin moieties installed at the distal end of the PEG tethered chains were prepared by the autoreduction of HAuCl₄ catalyzed by α-biotinyl-PEG-block-poly[2-(N,N-dimethylamino)ethyl methacrylate] (biotinyl-PEG/PAMA) in aqueous medium at room temperature. The size of the gold nanoparticles was controllable in a range of 6-13 nm by changing the initial Au³⁺/polymer ratio, while retaining their narrow size distribution. The dispersion stability of the nanoparticles in aqueous medium was extremely high even under the condition of salt concentration as high as I = 2.0. Biotinyl-PEG/PAMA-anchored gold nanoparticles underwent specific aggregation in the presence of streptavidin, revealing their promising utility as colloidal sensing systems applicable under biological condition.

Original language	English
Pages (from-to)	561-564
Number of pages	4
Journal	Langmuir
Volume	20
Issue number	3
DOIs	https://doi.org/10.1021/la035653i
Publication status	Published - 3 Feb 2004

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10.1021/la035653i

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@article{e58c76a877094658b0b42a8c3d3e2b3d,

title = "Preparation of functionally PEGylated gold nanoparticles with narrow distribution through autoreduction of auric cation by α-Biotinyl-PEG-block-[poly(2-(N,N-dimethylamino)ethyl methacrylate)]",

abstract = "PEGylated gold nanoparticles with biotin moieties installed at the distal end of the PEG tethered chains were prepared by the autoreduction of HAuCl4 catalyzed by α-biotinyl-PEG-block-poly[2-(N,N-dimethylamino)ethyl methacrylate] (biotinyl-PEG/PAMA) in aqueous medium at room temperature. The size of the gold nanoparticles was controllable in a range of 6-13 nm by changing the initial Au3+/polymer ratio, while retaining their narrow size distribution. The dispersion stability of the nanoparticles in aqueous medium was extremely high even under the condition of salt concentration as high as I = 2.0. Biotinyl-PEG/PAMA-anchored gold nanoparticles underwent specific aggregation in the presence of streptavidin, revealing their promising utility as colloidal sensing systems applicable under biological condition.",

author = "Takehiko Ishii and Hidenori Otsuka and Kazunori Kataoka and Yukio Nagasaki",

year = "2004",

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doi = "10.1021/la035653i",

language = "English",

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pages = "561--564",

journal = "Langmuir",

issn = "0743-7463",

publisher = "American Chemical Society",

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Preparation of functionally PEGylated gold nanoparticles with narrow distribution through autoreduction of auric cation by α-Biotinyl-PEG-block-[poly(2-(N,N-dimethylamino)ethyl methacrylate)]. / Ishii, Takehiko; Otsuka, Hidenori; Kataoka, Kazunori et al.
In: Langmuir, Vol. 20, No. 3, 03.02.2004, p. 561-564.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - Preparation of functionally PEGylated gold nanoparticles with narrow distribution through autoreduction of auric cation by α-Biotinyl-PEG-block-[poly(2-(N,N-dimethylamino)ethyl methacrylate)]

AU - Ishii, Takehiko

AU - Otsuka, Hidenori

AU - Kataoka, Kazunori

AU - Nagasaki, Yukio

PY - 2004/2/3

Y1 - 2004/2/3

N2 - PEGylated gold nanoparticles with biotin moieties installed at the distal end of the PEG tethered chains were prepared by the autoreduction of HAuCl4 catalyzed by α-biotinyl-PEG-block-poly[2-(N,N-dimethylamino)ethyl methacrylate] (biotinyl-PEG/PAMA) in aqueous medium at room temperature. The size of the gold nanoparticles was controllable in a range of 6-13 nm by changing the initial Au3+/polymer ratio, while retaining their narrow size distribution. The dispersion stability of the nanoparticles in aqueous medium was extremely high even under the condition of salt concentration as high as I = 2.0. Biotinyl-PEG/PAMA-anchored gold nanoparticles underwent specific aggregation in the presence of streptavidin, revealing their promising utility as colloidal sensing systems applicable under biological condition.

AB - PEGylated gold nanoparticles with biotin moieties installed at the distal end of the PEG tethered chains were prepared by the autoreduction of HAuCl4 catalyzed by α-biotinyl-PEG-block-poly[2-(N,N-dimethylamino)ethyl methacrylate] (biotinyl-PEG/PAMA) in aqueous medium at room temperature. The size of the gold nanoparticles was controllable in a range of 6-13 nm by changing the initial Au3+/polymer ratio, while retaining their narrow size distribution. The dispersion stability of the nanoparticles in aqueous medium was extremely high even under the condition of salt concentration as high as I = 2.0. Biotinyl-PEG/PAMA-anchored gold nanoparticles underwent specific aggregation in the presence of streptavidin, revealing their promising utility as colloidal sensing systems applicable under biological condition.

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M3 - Letter

C2 - 15773075

AN - SCOPUS:1242265527

SN - 0743-7463

VL - 20

SP - 561

EP - 564

JO - Langmuir

JF - Langmuir

IS - 3

ER -

Preparation of functionally PEGylated gold nanoparticles with narrow distribution through autoreduction of auric cation by α-Biotinyl-PEG-block-[poly(2-(N,N-dimethylamino)ethyl methacrylate)]

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