PEGylation for biocompatible surface

Fouling corresponding to nonspecific protein adsorption is a key problem for many medical and biotechnological applications. The problem is most critical when complex biological media such as blood or blood plasma contact the surfaces of artificial materials. The proteins that adsorb on the biomaterial surface determine subsequent responses, including blood coagulation, platelet activation, complement activation and inflammation, and the final performance of the material. The development of technologies by which antifouling surfaces of biomedical materials can be prepared is a central challenge for contemporary research. Surface coatings based on poly(ethylene glycol) (PEG), a nontoxic and nonimmunogenic polymer, have been used for the modification of various biomedical surfaces (PEGylation). The high reactivity of PEG terminal makes the introduction of functional group easy to tether to the material's surface. In this chapter, we highlight the construction of the PEG modified surface and its application to biological and biomedical fields. A PEG modified biocompatible surface is prepared by the various and effective surface coating method for substances and shows the characteristic features based on the properties of PEG.