PEG-engineering surface for microfabricated cell spheroid array chip

Masahiro Ichino; Tomomi Satomi; Hidenori Otsuka; Akihiro Hirano; Kazunori Kataoka; Yukio Nagasaki

PEG-engineering surface for microfabricated cell spheroid array chip

Masahiro Ichino, Tomomi Satomi, Hidenori Otsuka, Akihiro Hirano, Kazunori Kataoka, Yukio Nagasaki

Department of Applied Chemistry

Research output: Contribution to conference › Paper › peer-review

Abstract

New high-throughput techniques based on tissue and cell microarrays will facilitate clinical and pharmaceutical analysis of molecular targets because living cells can monitor the targets through the physiological changes that are induced in them by exposure to drugs and environmental perturbations, such as toxicants, pathogens or other agents. PEG engineered surface was constructed on glass and gold surface by two different micropatterning technique, viz., a UV etching and a photo-lithography. The obtained surfaces were evaluated by the cultivation of endotherial cell in order to construct patterned feeder layer. The tumor hepatocyte spheroid array could be constructed on the endotherial feeder pattern.

Original language	English
Pages	2277
Number of pages	1
Publication status	Published - 2005
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 25 May 2005 → 27 May 2005

Conference

Conference	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	25/05/05 → 27/05/05

Keywords

Cell array
PEG
Spheroid
Surface

Cite this

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title = "PEG-engineering surface for microfabricated cell spheroid array chip",

abstract = "New high-throughput techniques based on tissue and cell microarrays will facilitate clinical and pharmaceutical analysis of molecular targets because living cells can monitor the targets through the physiological changes that are induced in them by exposure to drugs and environmental perturbations, such as toxicants, pathogens or other agents. PEG engineered surface was constructed on glass and gold surface by two different micropatterning technique, viz., a UV etching and a photo-lithography. The obtained surfaces were evaluated by the cultivation of endotherial cell in order to construct patterned feeder layer. The tumor hepatocyte spheroid array could be constructed on the endotherial feeder pattern.",

keywords = "Cell array, PEG, Spheroid, Surface",

author = "Masahiro Ichino and Tomomi Satomi and Hidenori Otsuka and Akihiro Hirano and Kazunori Kataoka and Yukio Nagasaki",

year = "2005",

language = "English",

pages = "2277",

note = "54th SPSJ Annual Meeting 2005 ; Conference date: 25-05-2005 Through 27-05-2005",

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TY - CONF

T1 - PEG-engineering surface for microfabricated cell spheroid array chip

AU - Ichino, Masahiro

AU - Satomi, Tomomi

AU - Otsuka, Hidenori

AU - Hirano, Akihiro

AU - Kataoka, Kazunori

AU - Nagasaki, Yukio

PY - 2005

Y1 - 2005

N2 - New high-throughput techniques based on tissue and cell microarrays will facilitate clinical and pharmaceutical analysis of molecular targets because living cells can monitor the targets through the physiological changes that are induced in them by exposure to drugs and environmental perturbations, such as toxicants, pathogens or other agents. PEG engineered surface was constructed on glass and gold surface by two different micropatterning technique, viz., a UV etching and a photo-lithography. The obtained surfaces were evaluated by the cultivation of endotherial cell in order to construct patterned feeder layer. The tumor hepatocyte spheroid array could be constructed on the endotherial feeder pattern.

AB - New high-throughput techniques based on tissue and cell microarrays will facilitate clinical and pharmaceutical analysis of molecular targets because living cells can monitor the targets through the physiological changes that are induced in them by exposure to drugs and environmental perturbations, such as toxicants, pathogens or other agents. PEG engineered surface was constructed on glass and gold surface by two different micropatterning technique, viz., a UV etching and a photo-lithography. The obtained surfaces were evaluated by the cultivation of endotherial cell in order to construct patterned feeder layer. The tumor hepatocyte spheroid array could be constructed on the endotherial feeder pattern.

KW - Cell array

KW - PEG

KW - Spheroid

KW - Surface

UR - http://www.scopus.com/inward/record.url?scp=33645634699&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645634699

SP - 2277

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

PEG-engineering surface for microfabricated cell spheroid array chip

Abstract

Conference

Keywords

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