@article{91c207b7d9704656b39e6edf53693368,
title = "Opposite effects of Trichostatin A on activation of mast cells by different stimulants",
abstract = "Mast cells (MCs) are activated upon stimulation via TLRs or FcεRI, contributing to immune protection and/or leading to allergic diseases. In the present study, the effects of Trichostatin A (TSA) on the activation of MCs were analyzed with bone marrow-derived (BM) MCs. TSA increased the transcription and protein secretion of IL-6 in case of LPS-stimulation, in contrast to the suppressive effect on IgE-mediated activation of BMMCs. Chromatin immunoprecipitation assay showed IgE-mediated signaling-specific suppression of transcription factors recruitment to the IL-6 promoter. TSA-treatment inhibited nuclear translocation of NF-κB following IgE-mediated, but not LPS-induced activation in MCs.",
keywords = "FcεRI, Mast cell, Pharmacology, Transcription factor, Trichostatin A",
author = "Wang, {Qing hui} and Chiharu Nishiyama and Nobuhiro Nakano and Shunsuke Kanada and Mutsuko Hara and Nao Kitamura and Naomi Shimokawa and Lu, {Chang long} and Hideoki Ogawa and Ko Okumura",
note = "Funding Information: We would like to thank members of the Atopy (Allergy) Research Center and the Department of Immunology for helpful discussions. We are grateful to Dr. M. Yoshida (RIKEN Advanced Science Institute) for his critical advice, Drs. K. Maeda, and D. Potaczek for their fruitful suggestion and assistance and Ms. M. Matsumoto for secretarial assistance. This work was supported in part by a Grant-in-Aid for Scientific Research (C) to C. N. from the Ministry of Education, Culture, Sports, Science and Technology of Japan .",
year = "2010",
month = jun,
doi = "10.1016/j.febslet.2010.03.047",
language = "English",
volume = "584",
pages = "2315--2320",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "11",
}