Nickel-mediated regio- and chemoselective carboxylation of alkynes in the presence of carbon dioxide

Shinichi Saito, Satomi Nakagawa, Toru Koizumi, Kyoko Hirayama, Yoshinori Yamamoto

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Abstract

Alkynes are carboxylated in a highly regio- and chemoselective manner in the presence of Ni(cod)2, DBU, and CO2 to give the carboxylated products in good yields. The reaction was carried out under very mild conditions (CO2 1 atm, 0°C) in the presence of a stoichiometric amount of alkynes, conjugated enynes, or diynes. The high selectivity observed in the reaction would be explained in terms of the stability and the reactivity of the intermediates.

Original languageEnglish
Pages (from-to)3975-3978
Number of pages4
JournalJournal of Organic Chemistry
Volume64
Issue number11
DOIs
Publication statusPublished - 28 May 1999

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