Monooxygenase-catalyzed regioselective hydroxylation for the synthesis of hydroxyequols

Takafumi Hashimoto, Daiki Nozawa, Katsuyuki Mukai, Akinobu Matsuyama, Kouji Kuramochi, Toshiki Furuya

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Monooxygenases exhibiting high activity and differing regioselectivity for the dietary isoflavone metabolite equol were discovered among enzymes in the HpaBC family by a genome mining approach. These enzymes enabled the one-step product-selective synthesis of 3′- and 6-hydroxyequols from equol and molecular oxygen.

Original languageEnglish
Pages (from-to)21826-21830
Number of pages5
JournalRSC Advances
Volume9
Issue number38
DOIs
Publication statusPublished - 2019

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