Microfluidic device for capturing circulating tumor cells - Separation by cell size and rigidity

Tomoki Konishi, Hiromasa Okano, Takahiro Suzuki, Shinya Ariyasu, Toshihiro Suzuki, Ryo Abe, Shin Aoki, Masanori Hayase

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Effect of fluid velocity on cell size sorting by a deterministic lateral displacement (DLD) device was studied. Circulating tumor cells (CTCs) tends to be larger compared to benign blood cells, and DLD sorting devices have been studied for CTC separation. However, high separation efficiency is not expected by only size sorting. We focused on cell deformability, and effect of fluid velocity on separation behavior in a simple DLD device was observed. It was found that benign lymphocytes tends to behave like smaller cells at high velocity, while no obvious difference along fluid velocity was observed with cultured SP2/0 tumor cells.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages600-602
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 1 Jan 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 26 Oct 201430 Oct 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/TerritoryUnited States
CitySan Antonio
Period26/10/1430/10/14

Keywords

  • Circulating tumor cells
  • Deterministic lateral displacement
  • Microfluidic device

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