Mechanisms of the anti-aging and prolongevity effects of caloric restriction: Evidence from studies of genetically modified animals

Shunsuke Hoshino, Masaki Kobayashi, Yoshikazu Higami

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

It is widely accepted that caloric restriction (CR) extends lifespan and suppresses various pathophysiological changes. CR suppresses growth hormone/insulin-like growth factor signaling and mechanistic target of rapamycin complex 1 activity, activates sirtuin and enhances mitochondrial redox regulation, but the exact mechanisms are still under debate. In this review, we discuss the mechanisms of CR using evidence from studies of animals that were genetically modified according to recent advances in molecular and genetic technologies, from the viewpoint of the adaptive response hypothesis proposed by Holliday (1989). We then explain the beneficial actions of CR, classified according to whether they operate under feeding or fasting conditions.

Original languageEnglish
Pages (from-to)2243-2251
Number of pages9
JournalAging
Volume10
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • Aging
  • Caloric restriction
  • Growth hormone/insulin-like growth factor 1
  • Mitochondria/redox regulation
  • Remodeling of white adipose tissue

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