Irradiation effect of a submillimeter wave from 420 GHz gyrotron on amyloid peptides in vitro

Takayasu Kawasaki, Yuusuke Yamaguchi, Tomomi Ueda, Yuya Ishikawa, Toyonari Yaji, Toshiaki Ohta, Koichi Tsukiyama, Toshitaka Idehara, Masatoshi Saiki, Masahiko Tani

Research output: Contribution to journalArticlepeer-review

Abstract

On using the far-infrared radiation system, whether the irradiation effect is thermal or non-thermal is controversial. We irradiated amyloid peptides that are causal factors for amyloidosis by using a submillimeter wave from 420 GHz gyrotron. Fluorescence reagent assay, optical and electron microscopies, and synchrotron-radiation infrared microscopy showed that the irradiation increased the fibrous conformation of peptides at room temperature for 30 min. The temperature increase on the sample was only below 5 K, and a simple heating up to 318 K hardly induced the fibril formation. Therefore, the amyloid aggregation was driven by the far-infrared radiation with little thermal effect.

Original languageEnglish
Pages (from-to)5341-5351
Number of pages11
JournalBiomedical Optics Express
Volume11
Issue number9
DOIs
Publication statusPublished - 2021

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